Circadian Clock Genes in Diabetic Kidney Disease (DKD)

被引：8

作者：

Olaoye, Olanrewaju A. ^{[1
]}

Masten, Sarah H. ^{[1
]}

Mohandas, Rajesh ^{[1
,2
]}

Gumz, Michelle L. ^{[1
,2
,3
]}

机构：

[1] Univ Florida, Dept Med, Div Nephrol Hypertens & Renal Transplantat, 1600 SW Archer Rd,Box 100224, Gainesville, FL 32610 USA

[2] North Florida South Georgia Vet Hlth Syst, Gainesville, FL 32608 USA

[3] Univ Florida, Dept Biochem & Mol Biol, Gainesville, FL 32610 USA

来源：

CURRENT DIABETES REPORTS | 2019年 / 19卷 / 07期

关键词：

Circadian rhythm; Renal function; HIF; Shift work; BMAL1; PROTEIN PERIOD 1; GLOMERULAR-FILTRATION-RATE; AMBULATORY BLOOD-PRESSURE; HYPERTENSIVE PATIENTS; SODIUM-TRANSPORT; EXPRESSION; RHYTHM; MOUSE; PER1; NEPHROPATHY;

D O I：

10.1007/s11892-019-1156-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of ReviewThe purpose of this review is to provide a brief summary about the current state of knowledge regarding the circadian rhythm in the regulation of normal renal function.Recent FindingsThere is a lack of information regarding how the circadian clock mechanisms may contribute to the development of diabetic kidney disease. We discuss recent findings regarding mechanisms that are established in diabetic kidney disease and are known to be linked to the circadian clock as possible connections between these two areas.SummaryHere, we hypothesize various mechanisms that may provide a link between the clock mechanism and kidney disease in diabetes based on available data from humans and rodent models.

引用

页数：7

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