Copper-catalysed direct radical alkenylation of alkyl bromides

被引：44

作者：

Zhang, Xu ^{[1
]}

Yi, Hong ^{[1
]}

Liao, Zhixiong ^{[1
]}

Zhang, Guoting ^{[1
]}

Fan, Chao ^{[1
]}

Qin, Chu ^{[1
]}

Liu, Jie ^{[1
]}

Lei, Aiwen ^{[1
,2
]}

机构：

[1] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China

[2] Jiangxi Normal Univ, Natl Res Ctr Carbohydrate Synth, Nanchang 330022, Jiangxi, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2014年 / 12卷 / 35期

基金：

高等学校博士学科点专项科研基金; 中国国家自然科学基金;

关键词：

HECK-TYPE REACTION; BENZYL; HALIDES; POLYMERIZATION; SUBSTITUTION; CYCLIZATION; OLEFIN; ARYL;

D O I：

10.1039/c4ob00813h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-catalysed direct radical alkenylation of various benzyl bromides and a-carbonyl alkyl bromides has been developed. Compared with the recent radical alkenylations which mostly focused on secondary or tertiary alkyl halides, this transformation shows good reactivity to primary alkyl halides and tertiary, secondary alkyl halides were also tolerated. The key initiation step of this transformation is a copper-induced single-electron reduction of C-Br bonds to generate alkyl radical species.

引用

页码：6790 / 6793

页数：4

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