γ-Induced thermal stability and thermal studies on timolol β-blocker

被引：6

作者：

Abou-Sekkina, MM ^{[1
]}

El-Ries, MA

Molokhia, AM

Rabbie, N

Wassel, AA

机构：

[1] Tanta Univ, Fac Sci, Tanta, Egypt

[2] Natl Org Drug Control & Res, Giza, Egypt

[3] Natl Inst Stand, Radiat Dept, Giza, Egypt

来源：

JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY | 2002年 / 68卷 / 03期

关键词：

beta-blocker; HPLC; IR; gamma-radiolysis; thermal stability; timolol; UV; X-ray;

D O I：

10.1023/A:1016111126998

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

Timolol drug, has been investigated by using X-ray diffraction analysis, thermogravimetry (TG), differential thermal analysis (DTA), IR, HPLC and electronic absorption spectra (UV/Vis), before and after exposure to gamma-radiation. The interaction of gamma-rays with timolol has been studied. Results obtained indicated high stability toward gamma-absorbed dose over the range 5-50 kGy.

引用

页码：1017 / 1023

页数：7

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