Melanogenesis inhibitory pregnane glycosides from Cynanchum atratum

被引：12

作者：

Jin, Qinghao ^{[1
]}

Han, Xiang Hua ^{[1
]}

Yun, Cheong-Yong ^{[1
]}

Lee, Chul ^{[1
]}

Lee, Jin Woo ^{[1
]}

Lee, Dongho ^{[2
]}

Lee, Mi Kyeong ^{[1
]}

Jung, Sang-Hun ^{[3
]}

Hong, Jin Tae ^{[1
]}

Kim, Youngsoo ^{[1
]}

Hwang, Bang Yeon ^{[1
]}

机构：

[1] Chungbuk Natl Univ, Coll Pharm, Cheongju 28160, South Korea

[2] Korea Univ, Sch Life Sci & Biotechnol, Seoul 02841, South Korea

[3] Chungnam Natl Univ, Coll Pharm, Daejeon 34134, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2018年 / 28卷 / 07期

基金：

新加坡国家研究基金会;

关键词：

Cynanchum atratum; Asclepiadaceae; Pregnane glycosides; alpha-MSH; Melanogenesis inhibitor; C-21 STEROIDAL GLYCOSIDES; ROOTS; CONSTITUENTS; TYROSINASE;

D O I：

10.1016/j.bmcl.2018.01.004

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Bioassay-guided fractionation of the methanolic extract from the roots of Cynanchum atratum has resulted in the isolation of three new pregnane glycosides (1-3) along with four known compounds (4-7). Their structures were identified by analysis of the spectroscopic data including extensive 2D NMR. All of the isolates were evaluated for their potential to inhibit the melanin production in a-melanocyte stimulating hormone (alpha-MSH)-activated B16 melanoma cells. Of these, compounds 4-7 dosedependently inhibited the melanin production with the IC50 values ranging from 4 mu M to 33 mu M. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：1252 / 1256

页数：5

共 20 条

[1] Twelve pregnane glycosides from Cynanchum atratum [J].

Bai, Hong ;

Li, Wei ;

Asada, Yoshihisa ;

Satou, Tadaaki ;

Wang, Yuanshu ;

Koike, Kazuo .

STEROIDS, 2009, 74 (02) :198-207

[2] Pregnane glycosides from Cynanchum atratum [J].

Bai, Hong ;

Li, Wei ;

Koike, Kazuo .

STEROIDS, 2008, 73 (01) :96-103

[3]

Bensky D., 2004, CHINESE HERBAL MED M, P413

[4] Human skin pigmentation: melanocytes modulate skin color in response to stress [J].

Costin, Gertrude-E. ;

Hearing, Vincent J. .

FASEB JOURNAL, 2007, 21 (04) :976-994

[5] Bioactive constituents of the roots of Cynanchum atratum [J].

Day, SH ;

Wang, JP ;

Won, SJ ;

Lin, CN .

JOURNAL OF NATURAL PRODUCTS, 2001, 64 (05) :608-611

[6] Murine tyrosinase Inhibitors from Cynanchum bungei and evaluation of in vitro and in vivo depigmenting activity [J].

Ding, Hsiou-Yu ;

Chang, Te-Sheng ;

Shen, Hung-Chang ;

Tai, Sorgan Shou-Ku .

EXPERIMENTAL DERMATOLOGY, 2011, 20 (09) :720-724

[7] Leptolide, a new furanocembranolide diterpene from Leptogorgia alba [J].

Gutiérrez, M ;

Capson, TL ;

Guzmán, CM ;

González, J ;

Ortega-Barría, E ;

Quiñoá, E ;

Riguera, R .

JOURNAL OF NATURAL PRODUCTS, 2005, 68 (04) :614-616

[8] THE EXPRESSION OF TYROSINASE, TYROSINASE-RELATED PROTEIN-1 AND PROTEIN-2 (TRP1 AND TRP2), THE SILVER PROTEIN, AND A MELANOGENIC INHIBITOR IN HUMAN-MELANOMA CELLS OF DIFFERING MELANOGENIC ACTIVITIES [J].

KAMEYAMA, K ;

SAKAI, C ;

KUGE, S ;

NISHIYAMA, S ;

TOMITA, Y ;

ITO, S ;

WAKAMATSU, K ;

HEARING, VJ .

PIGMENT CELL RESEARCH, 1995, 8 (02) :97-104

[9] Chemical constituents from the roots of Cynanchum paniculatum and their cytotoxic activity [J].

Kim, Chung Sub ;

Oh, Ju Yeoun ;

Choi, Sang Un ;

Lee, Kang Ro .

CARBOHYDRATE RESEARCH, 2013, 381 :1-5

[10] Anti-acetylcholinesterase and anti-amnesic activities of a pregnane glycoside, cynatroside B, from Cynanchum atratum [J].

Lee, KY ;

Yoon, JS ;

Kim, ES ;

Kang, SY ;

Kim, YC .

PLANTA MEDICA, 2005, 71 (01) :7-11

← 1 2 →