Recent Advances in Biodegradable Conducting Polymers and Their Biomedical Applications

被引:173
作者
Kenry [1 ]
Liu, Bin [1 ]
机构
[1] Natl Univ Singapore, Dept Chem & Biomol Engn, 4 Engn Dr 4, Singapore 117585, Singapore
关键词
HUMAN GROWTH-HORMONE; CONJUGATED POLYMERS; IN-VIVO; HIGHLY FLUORESCENT; ELECTROSPUN NANOFIBERS; SEMICONDUCTING POLYMER; SYNTHETIC-POLYMERS; CONTROLLED-RELEASE; ANILINE OLIGOMERS; CHEMICAL SENSORS;
D O I
10.1021/acs.biomac.8b00275
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The growing importance of biodegradable conducting polymers (CPs) have fueled the rapid development of this unique class of polymeric materials in recent years. Possessing both the electrical conductivity approaching those of metallic conductors and the biodegradability of biocompatible polymers, biodegradable CPs are highly sought after. In fact, they have emerged as the ideal biomaterials, having immense potential for augmenting a wide range of practical biomedical applications. Herein, we provide a broad overview of recent advances in the development of biodegradable CPs and their biomedical applications. We first introduce the fundamentals of conducting and biodegradable polymers, followed by discussions on the major strategies currently used to fabricate biodegradable CPs. We then highlight the potential biomedical applications of biodegradable CPs (specifically those for tissue engineering, regenerative medicine, and biomedical imaging as well as biomedical implants, bioelectronics devices, and consumer electronics). We conclude this review by offering our perspectives on the current challenges and future opportunities facing the development and practical applications of biodegradable CPs.
引用
收藏
页码:1783 / 1803
页数:21
相关论文
共 144 条
[1]  
Asti A, 2014, INT J ARTIF ORGANS, V37, P187, DOI [10.5301/ijao.5000307, 10.530/ijao.5000307]
[2]   Imaging of cell proliferation: Status and prospects [J].
Bading, James R. ;
Shieds, Anthony F. .
JOURNAL OF NUCLEAR MEDICINE, 2008, 49 :64S-80S
[3]   Conductive polymers: Towards a smart biomaterial for tissue engineering [J].
Balint, Richard ;
Cassidy, Nigel J. ;
Cartmell, Sarah H. .
ACTA BIOMATERIALIA, 2014, 10 (06) :2341-2353
[4]   Dynamic imine chemistry [J].
Belowich, Matthew E. ;
Stoddart, J. Fraser .
CHEMICAL SOCIETY REVIEWS, 2012, 41 (06) :2003-2024
[5]   Tissue Engineering and Regenerative Medicine: History, Progress, and Challenges [J].
Berthiaume, Francois ;
Maguire, Timothy J. ;
Yarmush, Martin L. .
ANNUAL REVIEW OF CHEMICAL AND BIOMOLECULAR ENGINEERING, VOL 2, 2011, 2 :403-430
[6]  
BHUTTA M.K., 2011, EC RES INT, V2011, P1, DOI DOI 10.1155/2011/474230
[7]   Development and characterization of biodegradable conductive polymers for the next generation of RF bio-resonators [J].
Boutry, Clementine M. ;
Sun, Wei ;
Strunz, Tobias ;
Chandrahalim, Hengky ;
Hierold, Christofer .
2010 IEEE INTERNATIONAL FREQUENCY CONTROL SYMPOSIUM (FCS), 2010, :258-261
[8]   How molecular imaging is speeding up antiangiogenic drug development [J].
Cai, Weibo ;
Rao, Jianghong ;
Gambhir, Sanjiv S. ;
Chen, Xiaoyuan .
MOLECULAR CANCER THERAPEUTICS, 2006, 5 (11) :2624-2633
[9]   Nanoparticles for cancer imaging: The good, the bad, and the promise [J].
Chapman, Sandra ;
Dobrovolskai, Marina ;
Farahani, Keyvan ;
Goodwin, Andrew ;
Joshi, Amit ;
Lee, Hakho ;
Meade, Thomas ;
Pomper, Martin ;
Ptak, Krzysztof ;
Rao, Jianghong ;
Singh, Ravi ;
Sridhar, Srinivas ;
Stern, Stephan ;
Wang, Andrew ;
Weaver, John B. ;
Woloschak, Gayle ;
Yang, Lily .
NANO TODAY, 2013, 8 (05) :454-460
[10]   Cardiovascular Molecular Imaging Focus on Clinical Translation [J].
Chen, Ian Y. ;
Wu, Joseph C. .
CIRCULATION, 2011, 123 (04) :425-443