HUMAN GROWTH-HORMONE;
CONJUGATED POLYMERS;
IN-VIVO;
HIGHLY FLUORESCENT;
ELECTROSPUN NANOFIBERS;
SEMICONDUCTING POLYMER;
SYNTHETIC-POLYMERS;
CONTROLLED-RELEASE;
ANILINE OLIGOMERS;
CHEMICAL SENSORS;
D O I:
10.1021/acs.biomac.8b00275
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
The growing importance of biodegradable conducting polymers (CPs) have fueled the rapid development of this unique class of polymeric materials in recent years. Possessing both the electrical conductivity approaching those of metallic conductors and the biodegradability of biocompatible polymers, biodegradable CPs are highly sought after. In fact, they have emerged as the ideal biomaterials, having immense potential for augmenting a wide range of practical biomedical applications. Herein, we provide a broad overview of recent advances in the development of biodegradable CPs and their biomedical applications. We first introduce the fundamentals of conducting and biodegradable polymers, followed by discussions on the major strategies currently used to fabricate biodegradable CPs. We then highlight the potential biomedical applications of biodegradable CPs (specifically those for tissue engineering, regenerative medicine, and biomedical imaging as well as biomedical implants, bioelectronics devices, and consumer electronics). We conclude this review by offering our perspectives on the current challenges and future opportunities facing the development and practical applications of biodegradable CPs.