Escherichia coli O157:H7 Vaccine Dose-Effect in Feedlot Cattle

被引：30

作者：

Moxley, Rodney A. ^{[1
]}

Smith, David R. ^{[1
]}

Luebbe, Matt ^{[2
]}

Erickson, Galen E. ^{[2
]}

Klopfenstein, Terry J. ^{[2
]}

Rogan, Dragan ^{[3
]}

机构：

[1] Univ Nebraska Lincoln, Dept Vet & Biomed Sci, Lincoln, NE 68583 USA

[2] Univ Nebraska Lincoln, Dept Anim Sci, Lincoln, NE 68583 USA

[3] Bioniche Life Sci, Belleville, ON, Canada

来源：

FOODBORNE PATHOGENS AND DISEASE | 2009年 / 6卷 / 07期

关键词：

III SECRETED PROTEINS; ADULT BEEF-CATTLE; TERMINAL RECTUM; EXPERIMENTAL-INFECTION; ANTIBODY-RESPONSES; 0157-H7; INFECTIONS; 2-DOSE REGIMEN; COLONIZATION; O157-H7; BOVINE;

D O I：

10.1089/fpd.2009.0297

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

A clinical trial conducted during the summer of 2006 evaluated effects of two- and three-dose regimens of an Escherichia coli O157 vaccine product on the probability of detecting E. coli O157:H7 in feces and colonization of the terminal rectum. The three-dose regimen significantly reduced the probability for cattle to shed E. coli O157:H7 in feces 65% compared to placebo-treated cattle. A dose-effect was demonstrated because a two- dose regimen of the vaccine product was intermediate in effect. These results are consistent with previous estimates of vaccine efficacy against fecal shedding, and agree with our previous finding that efficacy of two or three doses of this vaccine product exhibit a dose-response.

引用

页码：879 / 884

页数：6

共 28 条

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