Structure and function of the protein tyrosine phosphatases

被引：309
作者：
Fauman, EB [1 ]
Saper, MA [1 ]
机构：
[1] UNIV MICHIGAN,DEPT BIOL CHEM,ANN ARBOR,MI 48109
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1996年 / 21卷 / 11期
关键词：
D O I：
10.1016/S0968-0004(96)10059-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The tyrosine and dual-specificity phosphatases are involved in signaling, cell growth and differentiation, and the cell cycle. The enzymes share a common catalytic mechanism mediated by an active site cysteine, arginine and aspartic acid. Supplementary domains assist in targeting and substrate specificity.
引用
收藏
页码：413 / 417
页数：5
相关论文
共 48 条
[1]  
ALTSCHUL SF, 1990, J MOL BIOL, V215, P403, DOI 10.1006/jmbi.1990.9999
[2]   CRYSTAL-STRUCTURE OF HUMAN PROTEIN-TYROSINE-PHOSPHATASE 1B [J].
BARFORD, D ;
FLINT, AJ ;
TONKS, NK .
SCIENCE, 1994, 263 (5152) :1397-1404
[3]   Structural basis for inhibition of receptor protein-tyrosine phosphatase-alpha by dimerization [J].
Bilwes, AM ;
denHertog, J ;
Hunter, T ;
Noel, JP .
NATURE, 1996, 382 (6591) :555-559
[4]  
Bliska J B, 1995, Trends Microbiol, V3, P125, DOI 10.1016/S0966-842X(00)88898-8
[5]   PROTEIN-TYROSINE PHOSPHATASES AS ADHESION RECEPTORS [J].
BRADYKALNAY, SM ;
TONKS, NK .
CURRENT OPINION IN CELL BIOLOGY, 1995, 7 (05) :650-657
[6]   CDC2 REGULATORY FACTORS [J].
COLEMAN, TR ;
DUNPHY, WG .
CURRENT OPINION IN CELL BIOLOGY, 1994, 6 (06) :877-882
[7]   EXPRESSION OF A HUMAN T-CELL PROTEIN-TYROSINE-PHOSPHATASE IN BABY HAMSTER-KIDNEY CELLS [J].
COOL, DE ;
TONKS, NK ;
CHARBONNEAU, H ;
FISCHER, EH ;
KREBS, EG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (18) :7280-7284
[8]   A CATALYTIC MECHANISM FOR THE DUAL-SPECIFIC PHOSPHATASES [J].
DENU, JM ;
DIXON, JE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (13) :5910-5914
[9]  
Eckstein JW, 1996, PROTEIN SCI, V5, P5
[10]   The x-ray crystal structures of Yersinia tyrosine phosphatase with bound tungstate and nitrate - Mechanistic implications [J].
Fauman, EB ;
Yuvaniyama, C ;
Schubert, HL ;
Stuckey, JA ;
Saper, MA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (31) :18780-18788
12345