Rhodium/Gold Dual Catalysis in Carbene sp2 C-H Functionalization/Conia-ene Cascade for the Stereoselective Synthesis of Diverse Spirocarbocycles

被引：18
作者：
Hunter, Arianne C. [1 ,2 ]
Chinthapally, Kiran [1 ,2 ]
Bain, Anae, I [1 ,2 ]
Stevens, Joseph C. [1 ,2 ]
Sharma, Indrajeet [1 ,2 ]
机构：
[1] Univ Oklahoma, Dept Chem & Biochem, 101 Stephenson Pkwy, Norman, OK 73019 USA
[2] Univ Oklahoma, Inst Nat Prod Applicat & Res Technol, 101 Stephenson Pkwy, Norman, OK 73019 USA
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2019年 / 361卷 / 12期
关键词：
dual catalysis; rhodium carbenoid; Conia-ene; spirocarbocycle; spirooxindole; CONIA-ENE; RING-CLOSURE; STEREOELECTRONIC CONTROL; BALDWIN RULES; GOLD; CYCLIZATION; INSERTION; ECONOMY; CYCLOPROPENATION; STEREOCENTERS;
D O I：
10.1002/adsc.201900079
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A Rh(II)/Au(I) catalyzed carbene cascade approach for the stereoselective synthesis of diverse spirocarbocycles is described. The cascade reaction involves a rhodium carbene initiated sp(2) C-H functionalization followed by a gold catalyzed Conia-ene cyclization. The cascade reaction accommodates a variety of aryl substituents as well as ring sizes and proceeds with high diastereoselectivity providing access to diverse spirocarbocycles.
引用
收藏
页码：2951 / 2958
页数：8
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