Rhodium/Gold Dual Catalysis in Carbene sp2 C-H Functionalization/Conia-ene Cascade for the Stereoselective Synthesis of Diverse Spirocarbocycles

被引：18

作者：

Hunter, Arianne C. ^{[1
,2
]}

Chinthapally, Kiran ^{[1
,2
]}

Bain, Anae, I ^{[1
,2
]}

Stevens, Joseph C. ^{[1
,2
]}

Sharma, Indrajeet ^{[1
,2
]}

机构：

[1] Univ Oklahoma, Dept Chem & Biochem, 101 Stephenson Pkwy, Norman, OK 73019 USA

[2] Univ Oklahoma, Inst Nat Prod Applicat & Res Technol, 101 Stephenson Pkwy, Norman, OK 73019 USA

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2019年 / 361卷 / 12期

关键词：

dual catalysis; rhodium carbenoid; Conia-ene; spirocarbocycle; spirooxindole; CONIA-ENE; RING-CLOSURE; STEREOELECTRONIC CONTROL; BALDWIN RULES; GOLD; CYCLIZATION; INSERTION; ECONOMY; CYCLOPROPENATION; STEREOCENTERS;

D O I：

10.1002/adsc.201900079

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A Rh(II)/Au(I) catalyzed carbene cascade approach for the stereoselective synthesis of diverse spirocarbocycles is described. The cascade reaction involves a rhodium carbene initiated sp(2) C-H functionalization followed by a gold catalyzed Conia-ene cyclization. The cascade reaction accommodates a variety of aryl substituents as well as ring sizes and proceeds with high diastereoselectivity providing access to diverse spirocarbocycles.

引用

页码：2951 / 2958

页数：8

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