Multi-layer PDMS films having antifouling property for biomedical applications

被引:18
作者
Mousavi, M. [1 ,2 ]
Ghaleh, H. [3 ]
Jalili, K. [1 ,2 ]
Abbasi, F. [1 ,2 ]
机构
[1] Sahand Univ Technol, Inst Polymer Mat, Tabriz, Iran
[2] Sahand Univ Technol, Fac Polymer Engn, Tabriz, Iran
[3] Univ Bonab, Dept Polymer Sci & Engn, Bonab 5551761167, Iran
关键词
Poly(dimethylsiloxane); surface-initiated atom transfer radical polymerization; Permeability; cell fouling resistance; mechanical properties; poly(oligo(ethylene glycol) methacrylate); SURFACE MODIFICATION; COATINGS; POLYMERIZATION; SILICONE; DEVICES;
D O I
10.1080/09205063.2020.1856300
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Poly(dimethylsiloxane) (PDMS) elastomer is now a well-known material for packaging implantable biomedical micro-devices owing to unique bulk properties such as biocompatibility, low toxicity, excellent rheological properties, good flexibility, and mechanical stability. Despite the desirable bulk characteristics, PDMS is generally regarded as a high-flux material for oxygen and water vapor to penetrate compared with other polymeric barrier materials, which is related to the defect-induced penetration through the packaging coating prepared by the traditional deposition techniques. Besides, its hydrophobic nature causes serious fouling problems and limits the practical application of PDMS-based devices. In this work, the performance of silicone thin films as a packaging layer was improved by the fabrication of the roller-casted multiple thin layers to minimize a defect-induced failure. To confer hydrophilicity and cell fouling resistance, high-density and well-defined poly(oligo(ethylene glycol) methacrylate) (POEGMA) brushes were tethered via the surface-initiated atom transfer radical polymerization (SI-ATRP) technique on the roller-casted multiple thin PDMS layers. The characteristics of fabricated substrates were determined by static water contact angle measurement, X-ray photoelectron spectroscopy, and attenuated total reflection-Fourier transform infrared spectroscopy. In vitro cell behavior of POEGMA-grafted PDMS substrates was evaluated to examine cell-fouling resistance.
引用
收藏
页码:678 / 693
页数:16
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