Investigation on metal elements in the brain tissues from DNTC patients

被引：7
作者：
Ide-Ektessabi, A [1 ]
Kawakami, T
Ishihara, R
Mizuno, Y
Takeuchi, T
机构：
[1] Kyoto Univ, Int Innovat Ctr, Kyoto 6068501, Japan
[2] Kyoto Univ, Dept Precis Engn, Kyoto 6068501, Japan
[3] Nagoya Univ, Grad Sch Med, Dept Psychiat, Nagoya, Aichi 4668550, Japan
[4] Obu Dementia Care Res & Training Ctr, Obu 4740031, Japan
来源：
JOURNAL OF ELECTRON SPECTROSCOPY AND RELATED PHENOMENA | 2004年 / 137卷
关键词：
mu-SRXRF; DNTC; Pb; elemental imaging;
D O I：
10.1016/j.elspec.2004.02.152
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
Trace metallic elements in human cells play important roles in various cell functions as metalloprotein, metalloenzyme or metallic ions. Diffuse neurofibrillary tangles with calcification (DNTC) is an atypical dementia and is characterized pathologically by diffuse neurofibrillary tangles without senile plaques. In this study, X-ray fluorescence (XRF) spectroscopy using synchrotron radiation (SR) was applied to determine the distribution and density of the ultra-trace elements in the brain tissues from DTNC patients. This method made it possible to determine trace metallic elements non-destructively. The trace metallic elements (such as Ca, Fe, Zn, and Pb) in the brain tissues were examined. Two-dimension imaging of the elements and relative quantification of the elements in the brains were performed. The lead concentrations were observed in the calcified blood vessel in the brains with DNTC. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：801 / 804
页数：4
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