Synthesis of novel poly(ethylene glycol) supported benzazepines:: the crucial role of PEG on the selectivity of an intramolecular Heck reaction

被引：44
作者：
Ribiere, Patrice
Declerck, Valerie
Nedellec, Yannig
Yadav-Bhatnagar, Neerja
Martinez, Jean
Lamaty, Frederic
机构：
[1] Univ Montpellier I, CNRS, LAPP, F-34095 Montpellier 5, France
[2] Univ Montpellier 2, CNRS, LAMMI, F-34095 Montpellier 5, France
[3] Aventis Pharma, F-93325 Romainville, France
来源：
TETRAHEDRON | 2006年 / 62卷 / 44期
关键词：
polymer supported chemistry; heterocycles; Heck reaction; nanoparticles; immobilization; palladium; solvent effects;
D O I：
10.1016/j.tet.2006.08.009
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Poly(ethylene glycol) (PEG 3400) was used as a soluble polymeric support for the synthesis of a series of novel benzazepines. The key step for the preparation of these heterocycles was a phosphine-free palladium-catalyzed Heck reaction. Palladium nanoparticles formed during the course of the reaction were characterized. The presence of PEG 3400 influenced the outcome of the reaction in terms of selectivity. (c) 2006 Elsevier Ltd. All rights reserved.
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收藏
页码：10456 / 10466
页数：11
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