Wearable smart sensor systems integrated on soft contact lenses for wireless ocular diagnostics

被引：733

作者：

Kim, Joohee ^{[1
]}

Kim, Minji ^{[1
]}

Lee, Mi-Sun ^{[1
]}

Kim, Kukjoo ^{[1
]}

Ji, Sangyoon ^{[1
]}

Kim, Yun-Tae ^{[2
]}

Park, Jihun ^{[1
]}

Na, Kyungmin ^{[3
]}

Bae, Kwi-Hyun ^{[4
]}

Kim, Hong Kyun ^{[5
]}

Bien, Franklin ^{[3
]}

Lee, Chang Young ^{[2
]}

Park, Jang-Ung ^{[1
]}

机构：

[1] Ulsan Natl Inst Sci & Technol, Ctr Smart Sensor Syst, Wearable Elect Res Grp, Sch Mat Sci & Engn,Sch Energy & Chem Engn, Ulsan 44919, South Korea

[2] Ulsan Natl Inst Sci & Technol, Sch Energy & Chem Engn, Sch Life Sci, Ulsan 44919, South Korea

[3] Ulsan Natl Inst Sci & Technol, Sch Elect & Comp Engn, Ulsan 44919, South Korea

[4] Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Endocrinol, Daegu 41944, South Korea

[5] Kyungpook Natl Univ, Sch Med, Dept Ophthalmol, Daegu 41944, South Korea

来源：

NATURE COMMUNICATIONS | 2017年 / 8卷

基金：

新加坡国家研究基金会;

关键词：

CARBON NANOTUBES; CONDUCTING-POLYMER; HYBRID STRUCTURES; GLUCOSE SENSOR; TRANSPARENT; GRAPHENE; ELECTRODES; DESIGN; IMMOBILIZATION; PERFORMANCE;

D O I：

10.1038/ncomms14997

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Wearable contact lenses which can monitor physiological parameters have attracted substantial interests due to the capability of direct detection of biomarkers contained in body fluids. However, previously reported contact lens sensors can only monitor a single analyte at a time. Furthermore, such ocular contact lenses generally obstruct the field of vision of the subject. Here, we developed a multifunctional contact lens sensor that alleviates some of these limitations since it was developed on an actual ocular contact lens. It was also designed to monitor glucose within tears, as well as intraocular pressure using the resistance and capacitance of the electronic device. Furthermore, in-vivo and in-vitro tests using a live rabbit and bovine eyeball demonstrated its reliable operation. Our developed contact lens sensor can measure the glucose level in tear fluid and intraocular pressure simultaneously but yet independently based on different electrical responses.

引用

页数：8

共 48 条

[1] Stretchable and Transparent Electrodes using Hybrid Structures of Graphene-Metal Nanotrough Networks with High Performances and Ultimate Uniformity [J].