The discordance between primary breast cancer lesions and pulmonary metastatic lesions in expression of aldehyde dehydrogenase 1-positive cancer cells

被引：8

作者：

Nogami, Tomohiro ^{[1
]}

Shien, Tadahiko ^{[1
]}

Tanaka, Takehiro ^{[2
]}

Doihara, Hiroyoshi ^{[1
]}

Taira, Naruto ^{[1
]}

Takabatake, Daisuke ^{[3
]}

Nishimura, Rieko ^{[4
]}

Nishiyama, Keiko ^{[1
]}

Mizoo, Taeko ^{[1
]}

Ohsumi, Shozo ^{[3
]}

机构：

[1] Okayama Univ Hosp, Dept Breast & Endocrine Surg, Okayama, Japan

[2] Okayama Univ Hosp, Dept Pathol, Okayama, Japan

[3] Shikoku Canc Ctr, Dept Breast Oncol, Matsuyama, Ehime, Japan

[4] Shikoku Canc Ctr, Dept Pathol, Matsuyama, Ehime, Japan

来源：

BREAST CANCER | 2014年 / 21卷 / 06期

关键词：

Breast cancer; Pulmonary metastases; ALDH1; LUNG METASTASES; STEM-CELLS; RESECTION; SURVIVAL; SURGERY; THERAPY; BENEFIT;

D O I：

10.1007/s12282-013-0445-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We evaluated the expression of aldehyde dehydrogenase 1 (ALDH1) between primary breast lesions and pulmonary metastatic (PM) lesions in breast cancer patients. We retrospectively analyzed the clinicopathological features and the expression statuses of ER, PR, HER2, Ki-67 and ALDH-1 in both primary and metastatic breast cancer lesions and evaluated the discordance rates in the expressions of these markers between the primary and metastatic lesions, and also the prognostic value of these factors. None of the PM patients had metastases at any other sites, and all had undergone curative breast cancer surgery. The pulmonary operation was partial resection in 15 (88 %) patients and lobectomy in 2 (12 %) patients. The median overall survival (OS) after resection of the PNs (OS) was 48 months. The discordance rates in the expressions of ER, PR, HER2, Ki67 and ALDH-1 between the primary and metastatic lesions were 0, 29, 21, 43 and 50 %, respectively. There was significant discordance in the biomarkers between the primary tumors and the metastatic lesions.

引用

页码：698 / 702

页数：5

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