Studies on thermoresponsive polymers: Phase behaviour, drug delivery and biomedical applications

被引：390
作者：
Gandhi, Arijit [1 ]
Paul, Abhijit [1 ]
Sen, Suma Oommen [1 ]
Sen, Kalyan Kumar [1 ]
机构：
[1] Gupta Coll Technol Sci, Dept Pharmaceut, Asansol 713301, W Bengal, India
来源：
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2015年 / 10卷 / 02期
关键词：
Thermoresponsive polymers; Phase transition; Drug delivery; Tissue engineering; N-ISOPROPYLACRYLAMIDE COPOLYMERS; CRITICAL SOLUTION TEMPERATURE; SMOOTH-MUSCLE-CELLS; SWELLING BEHAVIOR; AQUEOUS-SOLUTIONS; INTRACELLULAR UPTAKE; TRIBLOCK COPOLYMERS; POLY(VINYL ALCOHOL); TISSUE REGENERATION; POLY(ACRYLIC ACID);
D O I：
10.1016/j.ajps.2014.08.010
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The present review aims to highlight the applications of thermoresponsive polymers. Thermo-responsive polymers show a sharp change in properties upon a small or modest change in temperature. This behaviour can be utilized for the preparation of so-called 'smart' drug delivery systems, which mimic biological response behaviour to a certain extent. Such materials are used in the development of several applications, such as drug delivery systems, tissue engineering scaffolds and gene delivery. Advances in this field are particularly relevant to applications in the areas of regenerative medicine and drug delivery. This review addresses summary of the main applications of thermoresponsive polymers which are categorized based on their 3-dimensional structure; hydrogels, interpenetrating networks, micelles, films and particles. The physico-chemical behaviour underlying the phase transition is also discussed in brief. (C) 2015 Shenyang Pharmaceutical University. Production and hosting by Elsevier B.V. All rights reserved.
引用
收藏
页码：99 / 107
页数：9
相关论文
共 95 条
[1]   Thermally Controlled Intracellular Uptake System of Polymeric Micelles Possessing Poly(N-isopropylacrylamide)-Based Outer Coronas [J].
Akimoto, Jun ;
Nakayama, Masamichi ;
Sakai, Kiyotaka ;
Okano, Teruo .
MOLECULAR PHARMACEUTICS, 2010, 7 (04) :926-935
[2]   Temperature-Induced Intracellular Uptake of Thermoresponsive Polymeric Micelles [J].
Akimoto, Jun ;
Nakayama, Masamichi ;
Sakai, Kiyotaka ;
Okano, Teruo .
BIOMACROMOLECULES, 2009, 10 (06) :1331-1336
[3]   TEMPERATURE-RESPONSIVE INTERPENETRATING POLYMER NETWORKS CONSTRUCTED WITH POLY(ACRYLIC ACID) AND POLY(N,N-DIMETHYLACRYLAMIDE) [J].
AOKI, T ;
KAWASHIMA, M ;
KATONO, H ;
SANUI, K ;
OGATA, N ;
OKANO, T ;
SAKURAI, Y .
MACROMOLECULES, 1994, 27 (04) :947-952
[4]   Thermoresponsive self-assembled elastin-based nanoparticles for delivery of BMPs [J].
Bessa, Paulo C. ;
Machado, Raul ;
Nuernberger, Sylvia ;
Dopler, Daniela ;
Banerjee, Asmita ;
Cunha, Antonio M. ;
Carlos Rodriguez-Cabello, J. ;
Redl, Heinz ;
van Griensven, Martijn ;
Reis, Rui L. ;
Casal, Margarida .
JOURNAL OF CONTROLLED RELEASE, 2010, 142 (03) :312-318
[5]   Study on the sol-gel transition of xyloglucan hydrogels [J].
Brun-Graeppi, Amanda K. Andriola Silva ;
Richard, Cyrille ;
Bessodes, Michel ;
Scherman, Daniel ;
Narita, Tetsuharu ;
Ducouret, Guylaine ;
Merten, Otto-Wilhelm .
CARBOHYDRATE POLYMERS, 2010, 80 (02) :555-562
[6]  
Chen GP, 1997, BIOTECHNOL BIOENG, V53, P339
[7]   A study of thermoresponsive poly(N-isopropylacrylamide)/polyarginine bioconjugate non-viral transgene vectors [J].
Cheng, Nan ;
Liu, Wenguang ;
Cao, Zhiqiang ;
Ji, Weihang ;
Liang, Dongchun ;
Guo, Gang ;
Zhang, Jingyu .
BIOMATERIALS, 2006, 27 (28) :4984-4992
[8]   Novel cell patterning using microheater-controlled thermoresponsive plasma films [J].
Cheng, XH ;
Wang, YB ;
Hanein, Y ;
Böhringer, KF ;
Ratner, BD .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2004, 70A (02) :159-168
[9]   Release kinetics of benzoic acid and its sodium salt from a series of poly(N-isopropylacrylamide) matrices with various percentage crosslinking [J].
Coughlan, D. C. ;
Corrigan, O. I. .
JOURNAL OF PHARMACEUTICAL SCIENCES, 2008, 97 (01) :318-330
[10]   Drug-polymer interactions and their effect on thermoresponsive poly(N-isopropylacrylamide) drug delivery systems [J].
Coughlan, DC ;
Corrigan, OI .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2006, 313 (1-2) :163-174
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