Improved Condensation of 2-pyridyllithium Intermediates with Aldehydes: Application for the Synthesis of 2-(polyhydroxyalkyl)pyridines

被引：4

作者：

Comoy, Corinne ^{[1
]}

Petrignet, Julien ^{[1
]}

Banaszak, Estelle ^{[1
]}

Chartoire, Anthony ^{[1
]}

Fort, Yves ^{[1
]}

机构：

[1] Nancy Univ, CNRS, SRSMC, F-54506 Vandoeuvre Les Nancy, France

来源：

LETTERS IN ORGANIC CHEMISTRY | 2009年 / 6卷 / 01期

关键词：

Regioselective lithiation; n-BuLi/LiDMAE] superbase; 2-pyridinyllithium; 2-(polyhydroxyalkyl)pyridines; LITHIATION; CONVERSION;

D O I：

10.2174/157017809787003214

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The scope and the limitations of 3-chloro-2-pyridinyl lithium condensation to aldehydes were envisioned depending on metallation conditions or condensation time and temperatures. The procedure was applied to various aromatic, aliphatic or functionalized aldehydes to afford a new and efficient access to 2-(polyhydroxyalkyl) pyridines.

引用

页码：50 / 56

页数：7

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