A microRNA signature and TGF-β1 response were identified as the key master regulators for spaceflight response

被引：35

作者：

Beheshti, Afshin ^{[1
]}

Ray, Shayoni ^{[2
]}

Fogle, Homer ^{[1
]}

Berrios, Daniel ^{[2
]}

Costes, Sylvian V. ^{[3
]}

机构：

[1] NASA, Ames Res Ctr, WYLE, Moffett Field, CA 94035 USA

[2] NASA, Ames Res Ctr, USRA, Moffett Field, CA 94035 USA

[3] NASA, Ames Res Ctr, Space Biosci Div, Moffett Field, CA 94035 USA

来源：

PLOS ONE | 2018年 / 13卷 / 07期

关键词：

GENE-EXPRESSION; T-CELL; SIMULATED MICROGRAVITY; CANCER PROGRESSION; SPACE RADIATION; IMMUNE-SYSTEM; TGF-BETA; AGE; CARCINOGENESIS; IRRADIATION;

D O I：

10.1371/journal.pone.0199621

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Translating fundamental biological discoveries from NASA Space Biology program into health risk from space flights has been an ongoing challenge. We propose to use NASA GeneLab database to gain new knowledge on potential systemic responses to space. Unbiased systems biology analysis of transcriptomic data from seven different rodent datasets reveals for the first time the existence of potential "master regulators" coordinating a systemic response to microgravity and/or space radiation with TGF-beta 1 being the most common regulator. We hypothesized the space environment leads to the release of biomolecules circulating inside the blood stream. Through datamining we identified 13 candidate microRNAs (miRNA) which are common in all studies and directly interact with TGF-beta 1 that can be potential circulating factors impacting space biology. This study exemplifies the utility of the GeneLab data repository to aid in the process of performing novel hypothesis-based research.

引用

页数：19

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