Placental efficiency and adaptation: endocrine regulation

被引：247

作者：

Fowden, A. L. ^{[1
]}

Sferruzzi-Perri, A. N. ^{[1
]}

Coan, P. M. ^{[1
]}

Constancia, M. ^{[2
]}

Burton, G. J. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge CB2 3EG, England

[2] Univ Cambridge, Ctr Trophoblast Res, Dept Obstet & Gynaecol, Cambridge CB2 3EG, England

来源：

JOURNAL OF PHYSIOLOGY-LONDON | 2009年 / 587卷 / 14期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

GROWTH-FACTOR-I; AMINO-ACID-TRANSPORT; DIFFUSIONAL EXCHANGE CHARACTERISTICS; LEPTIN RECEPTOR EXPRESSION; MATERNAL-FETAL EXCHANGE; INTRAUTERINE GROWTH; LATE-GESTATION; NUTRIENT TRANSPORT; GUINEA-PIG; BIRTH-WEIGHT;

D O I：

10.1113/jphysiol.2009.173013

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Size at birth is critical in determining life expectancy and is dependent primarily on the placental supply of nutrients. However, the fetus is not just a passive recipient of nutrients from the placenta. It exerts a significant acquisitive drive for nutrients, which acts through morphological and functional adaptations in the placenta, particularly when the genetically determined drive for fetal growth is compromised by adverse intrauterine conditions. These adaptations alter the efficiency with which the placenta supports fetal growth, which results in optimal growth for prevailing conditions in utero. This review examines placental efficiency as a means of altering fetal growth, the morphological and functional adaptations that influence placental efficiency and the endocrine regulation of these processes.

引用

页码：3459 / 3472

页数：14

共 119 条

[51] The effect of a chronic maternal cortisol infusion on the late-gestation fetal sheep [J].

Jensen, EC ;

Gallaher, BW ;

Breier, BH ;

Harding, JE .

JOURNAL OF ENDOCRINOLOGY, 2002, 174 (01) :27-36

[52] BETAMETHASONE AND THE RHESUS FETUS - MULTI-SYSTEMIC EFFECTS [J].

JOHNSON, JWC ;

MITZNER, W ;

LONDON, WT ;

PALMER, AE ;

SCOTT, R .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1979, 133 (06) :677-684

[53] Regulation of placental nutrient transport - A review [J].

Jones, H. N. ;

Powell, T. L. ;

Jansson, T. .

PLACENTA, 2007, 28 (8-9) :763-774

[54] Cortisol stimulates system A amino acid transport and SNAT2 expression in a human placental cell line (BeWo) [J].

Jones, Helen N. ;

Ashworth, Cheryl J. ;

Page, Ken R. ;

McArdle, Harry J. .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2006, 291 (03) :E596-E603

[55] High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57/BL6 mice [J].

Jones, Helen N. ;

Woollett, Laura A. ;

Barbour, Nicolette ;

Prasad, Puttur D. ;

Powell, Theresa L. ;

Jansson, Thomas .

FASEB JOURNAL, 2009, 23 (01) :271-278

[56] INSULIN-LIKE GROWTH-FACTOR-I STIMULATES AMINO-ACID-UPTAKE BY THE CULTURED HUMAN PLACENTAL TROPHOBLAST [J].

KARL, PI .

JOURNAL OF CELLULAR PHYSIOLOGY, 1995, 165 (01) :83-88

[57] Antenatal dexamethasone:: Effect on ovine placental 11,β-hydroxysteroid dehydrogenase type 2 expression and fetal growth [J].

Kerzner, LS ;

Stonestreet, BS ;

Wu, KY ;

Sadowska, G ;

Malee, MP .

PEDIATRIC RESEARCH, 2002, 52 (05) :706-712

[58]

KNISS DA, 1994, J REPROD MED, V39, P249

[59] Factors affecting placental traits and relationships of placental traits with neonatal behaviour in goat [J].

Konyali, A. ;

Tolu, C. ;

Das, G. ;

Savas, T. .

ANIMAL REPRODUCTION SCIENCE, 2007, 97 (3-4) :394-401

[60]

Kurtz H, 1999, ANAT EMBRYOL, V200, P335

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