Placental efficiency and adaptation: endocrine regulation

被引：247

作者：

Fowden, A. L. ^{[1
]}

Sferruzzi-Perri, A. N. ^{[1
]}

Coan, P. M. ^{[1
]}

Constancia, M. ^{[2
]}

Burton, G. J. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge CB2 3EG, England

[2] Univ Cambridge, Ctr Trophoblast Res, Dept Obstet & Gynaecol, Cambridge CB2 3EG, England

来源：

JOURNAL OF PHYSIOLOGY-LONDON | 2009年 / 587卷 / 14期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

GROWTH-FACTOR-I; AMINO-ACID-TRANSPORT; DIFFUSIONAL EXCHANGE CHARACTERISTICS; LEPTIN RECEPTOR EXPRESSION; MATERNAL-FETAL EXCHANGE; INTRAUTERINE GROWTH; LATE-GESTATION; NUTRIENT TRANSPORT; GUINEA-PIG; BIRTH-WEIGHT;

D O I：

10.1113/jphysiol.2009.173013

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Size at birth is critical in determining life expectancy and is dependent primarily on the placental supply of nutrients. However, the fetus is not just a passive recipient of nutrients from the placenta. It exerts a significant acquisitive drive for nutrients, which acts through morphological and functional adaptations in the placenta, particularly when the genetically determined drive for fetal growth is compromised by adverse intrauterine conditions. These adaptations alter the efficiency with which the placenta supports fetal growth, which results in optimal growth for prevailing conditions in utero. This review examines placental efficiency as a means of altering fetal growth, the morphological and functional adaptations that influence placental efficiency and the endocrine regulation of these processes.

引用

页码：3459 / 3472

页数：14

共 119 条

[21] Breed, litter and parity effects on placental weight and placentome number, and consequences for the neonatal behaviour of the lamb [J].

Dwyer, CM ;

Calvert, SK ;

Farish, M ;

Donbavand, J ;

Pickup, HE .

THERIOGENOLOGY, 2005, 63 (04) :1092-1110

[22]

Efstratiadis A, 1998, INT J DEV BIOL, V42, P955

[23] Hormonal regulation of glucose and system A amino acid transport in first trimester placental villous fragments [J].

Ericsson, A ;

Hamark, B ;

Jansson, N ;

Johansson, BR ;

Powell, TL ;

Jansson, T .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2005, 288 (03) :R656-R662

[24] The maternal endocrine environment in the low-protein model of intra-uterine growth restriction [J].

Fernandez-Twinn, DS ;

Ozanne, SE ;

Ekizoglou, S ;

Doherty, C ;

James, L ;

Gusterson, B ;

Hales, CN .

BRITISH JOURNAL OF NUTRITION, 2003, 90 (04) :815-822

[25] MATERNAL AND FETAL INFLUENCES ON UTERINE AND CONCEPTUS DEVELOPMENT IN THE COW .1. GROWTH OF TISSUES OF THE GRAVID UTERUS [J].

FERRELL, CL .

JOURNAL OF ANIMAL SCIENCE, 1991, 69 (05) :1945-1953

[26] Placental transport of leucine in a porcine model of low birth weight [J].

Finch, AM ;

Yang, LG ;

Nwagwu, MO ;

Page, KR ;

McArdle, HJ ;

Ashworth, CJ .

REPRODUCTION, 2004, 128 (02) :229-235

[27] The IGF axis and placental function [J].

Forbes, Karen ;

Westwood, Melissa .

HORMONE RESEARCH, 2008, 69 (03) :129-137

[28] The hungry fetus? Role of leptin as a nutritional signal before birth [J].

Forhead, Alison J. ;

Fowden, Abigail L. .

JOURNAL OF PHYSIOLOGY-LONDON, 2009, 587 (06) :1145-1152

[29] The placenta and intrauterine programming [J].

Fowden, A. L. ;

Forhead, A. J. ;

Coan, P. M. ;

Burton, G. J. .

JOURNAL OF NEUROENDOCRINOLOGY, 2008, 20 (04) :439-450

[30] Hormones as epigenetic signals in developmental programming [J].

Fowden, Abigail L. ;

Forhead, Alison J. .

EXPERIMENTAL PHYSIOLOGY, 2009, 94 (06) :607-625

← 1 2 3 4 5 6 7 8 9 10 →