Placental efficiency and adaptation: endocrine regulation

被引：240
作者：
Fowden, A. L. [1 ]
Sferruzzi-Perri, A. N. [1 ]
Coan, P. M. [1 ]
Constancia, M. [2 ]
Burton, G. J. [1 ]
机构：
[1] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge CB2 3EG, England
[2] Univ Cambridge, Ctr Trophoblast Res, Dept Obstet & Gynaecol, Cambridge CB2 3EG, England
来源：
JOURNAL OF PHYSIOLOGY-LONDON | 2009年 / 587卷 / 14期
基金：
英国生物技术与生命科学研究理事会; 英国惠康基金;
关键词：
GROWTH-FACTOR-I; AMINO-ACID-TRANSPORT; DIFFUSIONAL EXCHANGE CHARACTERISTICS; LEPTIN RECEPTOR EXPRESSION; MATERNAL-FETAL EXCHANGE; INTRAUTERINE GROWTH; LATE-GESTATION; NUTRIENT TRANSPORT; GUINEA-PIG; BIRTH-WEIGHT;
D O I：
10.1113/jphysiol.2009.173013
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Size at birth is critical in determining life expectancy and is dependent primarily on the placental supply of nutrients. However, the fetus is not just a passive recipient of nutrients from the placenta. It exerts a significant acquisitive drive for nutrients, which acts through morphological and functional adaptations in the placenta, particularly when the genetically determined drive for fetal growth is compromised by adverse intrauterine conditions. These adaptations alter the efficiency with which the placenta supports fetal growth, which results in optimal growth for prevailing conditions in utero. This review examines placental efficiency as a means of altering fetal growth, the morphological and functional adaptations that influence placental efficiency and the endocrine regulation of these processes.
引用
收藏
页码：3459 / 3472
页数：14
相关论文
共 119 条
  • [1] Dexamethasone-induced intrauterine growth restriction impacts the placental prolactin family, insulin-like growth factor-II and the Akt signaling pathway
    Ain, R
    Canham, LN
    Soares, MJ
    [J]. JOURNAL OF ENDOCRINOLOGY, 2005, 185 (02) : 253 - 263
  • [2] Allen WR, 2002, REPRODUCTION, V123, P445, DOI 10.1530/rep.0.1230445
  • [3] Regulation of placental efficiency for nutrient transport by imprinted genes
    Angiolini, E
    Fowden, A
    Coan, P
    Sandovici, I
    Smith, P
    Dean, W
    Burton, G
    Tycko, B
    Reik, W
    Sibley, C
    Constância, M
    [J]. PLACENTA, 2006, 27 : S98 - S102
  • [4] [Anonymous], [No title captured]
  • [5] Ashworth CJ, 2001, J REP FER S, P233
  • [6] PLACENTAL ANATOMY AND DIFFUSING-CAPACITY IN GUINEA-PIGS FOLLOWING LONG-TERM MATERNAL HYPOXIA
    BACON, BJ
    GILBERT, RD
    KAUFMANN, P
    SMITH, AD
    TREVINO, FT
    LONGO, LD
    [J]. PLACENTA, 1984, 5 (06) : 475 - 487
  • [7] Antenatal dexamethasone treatment leads to changes in gene expression in a murine late placenta
    Baisden, B.
    Sonne, S.
    Joshi, R. M.
    Ganapathy, V.
    Shekhawat, P. S.
    [J]. PLACENTA, 2007, 28 (10) : 1082 - 1090
  • [8] Barker D J, 1997, Rev Reprod, V2, P105, DOI 10.1530/ror.0.0020105
  • [9] BAUR R, 1977, ADV ANAT EMB CELL BI, P401
  • [10] A chronic low dose infusion of insulin-like growth factor I alters placental function but does not affect fetal growth
    Bloomfield, FH
    van Zijl, PL
    Bauer, MK
    Harding, JE
    [J]. REPRODUCTION FERTILITY AND DEVELOPMENT, 2002, 14 (07) : 393 - 400
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