We describe the first documented case of Covid-19 reinfection in Israel, out of only a handful such case worldwide, in a 20 year old otherwise healthy young woman. In the first occasion she was mildly symptomatic, whereas the second episode was apparently asymptomatic, except for tachycardia of 90/min, compared to 60/min in the first episode. The fact that out of 25 million infected persons worldwide only a handful of re-infected cases have been identified suggests that this is a rare phenomenon. Alternatively, it will be critical to rule out that new mutations are not introduced, which are not covered by existing immunity. (c) 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).