Evolution and functional cross-talk of protein post-translational modifications

被引：290

作者：

Beltrao, Pedro ^{[1
]}

Bork, Peer ^{[2
,3
]}

Krogan, Nevan J. ^{[4
,5
,6
]}

van Noort, Vera ^{[2
]}

机构：

[1] European Bioinformat Inst EMBL EBI, European Mol Biol Lab, Cambridge, England

[2] European Mol Biol Lab, Struct & Computat Biol Unit, D-69012 Heidelberg, Germany

[3] Max Delbruck Ctr Mol Med, Berlin, Germany

[4] Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA 94143 USA

[5] Calif Inst Quantitat Biosci, San Francisco, CA USA

[6] J David Gladstone Inst, San Francisco, CA USA

来源：

MOLECULAR SYSTEMS BIOLOGY | 2013年 / 9卷

基金：

美国国家卫生研究院;

关键词：

acetylation; evolution; phosphorylation; post-translational modifications; PTM cross-talk; LYSINE ACETYLATION; PHOSPHORYLATION SITES; COMPARATIVE GENOMICS; NATURAL-HISTORY; GLOBAL ANALYSIS; UBIQUITIN; REVEALS; KINASE; NETWORKS; TARGETS;

D O I：

10.1002/msb.201304521

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein post-translational modifications (PTMs) allow the cell to regulate protein activity and play a crucial role in the response to changes in external conditions or internal states. Advances in mass spectrometry now enable proteome wide characterization of PTMs and have revealed a broad functional role for a range of different types of modifications. Here we review advances in the study of the evolution and function of PTMs that were spurred by these technological improvements. We provide an overview of studies focusing on the origin and evolution of regulatory enzymes as well as the evolutionary dynamics of modification sites. Finally, we discuss different mechanisms of altering protein activity via post-translational regulation and progress made in the large-scale functional characterization of PTM function.

引用

页数：13

共 117 条

[1] Not just for Eukarya anymore: protein glycosylation in Bacteria and Archaea [J].

Abu-Qarn, Mehtap ;

Eichler, Jerry ;

Sharon, Nathan .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 2008, 18 (05) :544-550

[2] Spatial Exclusivity Combined with Positive and Negative Selection of Phosphorylation Motifs Is the Basis for Context-Dependent Mitotic Signaling [J].

Alexander, Jes ;

Lim, Daniel ;

Joughin, Brian A. ;

Hegemann, Bjoern ;

Hutchins, James R. A. ;

Ehrenberger, Tobias ;

Ivins, Frank ;

Sessa, Fabio ;

Hudecz, Otto ;

Nigg, Erich A. ;

Fry, Andrew M. ;

Musacchio, Andrea ;

Stukenberg, P. Todd ;

Mechtler, Karl ;

Peters, Jan-Michael ;

Smerdon, Stephen J. ;

Yaffe, Michael B. .

SCIENCE SIGNALING, 2011, 4 (179)

[3] Comparative genomics of protists: New insights into the evolution of eukaryotic signal transduction and gene regulation [J].

Anantharaman, Vivek ;

Iyer, Lakshminarayan M. ;

Aravind, L. .

ANNUAL REVIEW OF MICROBIOLOGY, 2007, 61 :453-475

[4] Evolution of Characterized Phosphorylation Sites in Budding Yeast [J].

Ba, Alex N. Nguyen ;

Moses, Alan M. .

MOLECULAR BIOLOGY AND EVOLUTION, 2010, 27 (09) :2027-2037

[5] Extensive DNA-binding specificity divergence of a conserved transcription regulator [J].

Baker, Christopher R. ;

Tuch, Brian B. ;

Johnson, Alexander D. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (18) :7493-7498

[6] Glycosylation/hydroxylation-induced stabilization of the collagen triple helix -: 4-trans-hydroxyproline in the Xaa position can stabilize the triple helix [J].

Bann, JG ;

Bächinger, HP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (32) :24466-24469

[7] Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response [J].

Beli, Petra ;

Lukashchuk, Natalia ;

Wagner, Sebastian A. ;

Weinert, Brian T. ;

Olsen, Jesper V. ;

Baskcomb, Linda ;

Mann, Matthias ;

Jackson, Stephen P. ;

Choudhary, Chunaram .

MOLECULAR CELL, 2012, 46 (02) :212-225

[8] Specificity and evolvability in eukaryotic protein interaction networks [J].

Beltrao, Pedro ;

Serrano, Luis .

PLOS COMPUTATIONAL BIOLOGY, 2007, 3 (02) :258-267

[9] Systematic Functional Prioritization of Protein Posttranslational Modifications [J].

Beltrao, Pedro ;

Albanese, Veronique ;

Kenner, Lillian R. ;

Swaney, Danielle L. ;

Burlingame, Alma ;

Villen, Judit ;

Lim, Wendell A. ;

Fraser, James S. ;

Frydman, Judith ;

Krogan, Nevan J. .

CELL, 2012, 150 (02) :413-425

[10] Evolution of Phosphoregulation: Comparison of Phosphorylation Patterns across Yeast Species [J].

Beltrao, Pedro ;

Trinidad, Jonathan C. ;

Fiedler, Dorothea ;

Roguev, Assen ;

Lim, Wendell A. ;

Shokat, Kevan M. ;

Burlingame, Alma L. ;

Krogan, Nevan J. .

PLOS BIOLOGY, 2009, 7 (06)

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