Uremic Sarcopenia and Its Possible Nutritional Approach

被引:64
作者
Noce, Annalisa [1 ,2 ]
Marrone, Giulia [1 ,2 ,3 ]
Ottaviani, Eleonora [1 ,2 ]
Guerriero, Cristina [1 ,2 ]
Di Daniele, Francesca [1 ,2 ,3 ]
Pietroboni Zaitseva, Anna [1 ,2 ]
Di Daniele, Nicola [1 ,2 ]
机构
[1] Univ Roma Tor Vergata, Dept Syst Med, UOC Internal Med, Ctr Hypertens, Via Montpellier 1, I-00133 Rome, Italy
[2] Univ Roma Tor Vergata, Dept Syst Med, Nephrol Unit, Via Montpellier 1, I-00133 Rome, Italy
[3] Univ Roma Tor Vergata, PhD Sch Appl Med, Surg Sci, Via Montpellier 1, I-00133 Rome, Italy
关键词
uremic sarcopenia; physical activity; hemodialysis; nutritional supplementation; intra-dialytic parenteral nutrition; ω -3 polyunsaturated fatty acids; CHRONIC KIDNEY-DISEASE; STAGE RENAL-DISEASE; INTRADIALYTIC PARENTERAL-NUTRITION; ESSENTIAL AMINO-ACIDS; ERYTHROCYTE GLUTATHIONE TRANSFERASE; SUBJECTIVE GLOBAL ASSESSMENT; X-RAY ABSORPTIOMETRY; LOW-PROTEIN INTAKE; SKELETAL-MUSCLE; MAINTENANCE HEMODIALYSIS;
D O I
10.3390/nu13010147
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Uremic sarcopenia is a frequent condition present in chronic kidney disease (CKD) patients and is characterized by reduced muscle mass, muscle strength and physical performance. Uremic sarcopenia is related to an increased risk of hospitalization and all-causes mortality. This pathological condition is caused not only by advanced age but also by others factors typical of CKD patients such as metabolic acidosis, hemodialysis therapy, low-grade inflammatory status and inadequate protein-energy intake. Currently, treatments available to ameliorate uremic sarcopenia include nutritional therapy (oral nutritional supplement, inter/intradialytic parenteral nutrition, enteral nutrition, high protein and fiber diet and percutaneous endoscopic gastrectomy) and a personalized program of physical activity. The aim of this review is to analyze the possible benefits induced by nutritional therapy alone or in combination with a personalized program of physical activity, on onset and/or progression of uremic sarcopenia.
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页码:1 / 29
页数:29
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