CYK-4/GAP provides a localized cue to initiate anteroposterior polarity upon fertilization

被引：97

作者：

Jenkins, Noah ^{[1
]}

Saam, Jennifer R. ^{[1
]}

Mango, Susan E. ^{[1
]}

机构：

[1] Univ Utah, Huntsman Canc Inst, Dept Oncol Sci, Salt Lake City, UT 84112 USA

来源：

SCIENCE | 2006年 / 313卷 / 5791期

关键词：

D O I：

10.1126/science.1130291

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Caenorhabditis elegans anteroposterior axis is established in response to fertilization by sperm. Here we present evidence that RhoA, the guanine nucleotide-exchange factor ECT-2, and the Rho guanosine triphosphatase-activating protein CYK-4 modulate myosin light-chain activity to create a gradient of actomyosin, which establishes the anterior domain. CYK-4 is enriched within sperm, and paternally donated CYK-4 is required for polarity. These data suggest that CYK-4 provides a molecular link between fertilization and polarity establishment in the one-cell embryo. Orthologs of CYK-4 are expressed in sperm of other species, which suggests that this cue may be evolutionarily conserved.

引用

页码：1298 / 1301

页数：4

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