Long noncoding RNA EMS connects c-Myc to cell cycle control and tumorigenesis

被引：65

作者：

Wang, Chenfeng ^{[1
,2
]}

Yang, Yang ^{[1
,2
]}

Zhang, Guang ^{[1
,2
]}

Li, Jingxin ^{[1
,2
]}

Wu, Xianning ^{[3
]}

Ma, Xiaoling ^{[4
]}

Shan, Ge ^{[1
,2
]}

Mei, Yide ^{[1
,2
]}

机构：

[1] USTC, Sch Life Sci, Hefei Natl Lab Phys Sci Microscale, Div Mol Med,Affiliated Hosp 1, Hefei 230027, Anhui, Peoples R China

[2] USTC, Sch Life Sci, CAS, Key Lab Innate Immun & Chron Dis, Hefei 230027, Anhui, Peoples R China

[3] USTC, Affiliated Hosp 1, Dept Thorac Surg, Hefei 230027, Anhui, Peoples R China

[4] USTC, Affiliated Hosp 1, Dept Lab Med, Hefei 230027, Anhui, Peoples R China

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2019年 / 116卷 / 29期

基金：

中国国家自然科学基金;

关键词：

c-Myc; lncRNA; E2F1; tumorigenesis; TARGET; GENE; E2F; TRANSCRIPTION; EXPRESSION; CANCER; LNCRNA; IDENTIFICATION; MECHANISMS; BIOGENESIS;

D O I：

10.1073/pnas.1903432116

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Deregulated expression of c-Myc is an important molecular hallmark of cancer. The oncogenic function of c-Myc has been largely attributed to its intrinsic nature as a master transcription factor. Here, we report the long noncoding RNA (lncRNA) E2F1 messenger RNA (mRNA) stabilizing factor (EMS) as a direct c-Myc transcriptional target. EMS functions as an oncogenic molecule by promoting G1/S cell cycle progression. Mechanistically, EMS cooperates with the RNA binding protein RALY to stabilize E2F1 mRNA, and thereby increases E2F1 expression. Furthermore, EMS is able to connect c-Myc to cell cycle control and tumorigenesis via modulating E2F1 mRNA stability. Together, these findings reveal a previously unappreciated mechanism through which c-Myc induces E2F1 expression and also implicate EMS as an important player in the regulation of c-Myc function.

引用

页码：14620 / 14629

页数：10

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