ZnCl2 catalyzed efficient synthesis of 1,3,4-oxadiazole and 1,3,4-thiadiazole

被引：4

作者：

Rahman, Md. A. ^{[1
]}

Karim, Mohammad R. ^{[1
]}

Arifuzzaman, Md. ^{[2
]}

Siddiquee, Tasneem A. ^{[1
]}

Mirza, Aminul H. ^{[3
]}

机构：

[1] Tennessee State Univ, Dept Chem, Nashville, TN 37209 USA

[2] Iowa State Univ, Dept Chem, Ames, IA 50011 USA

[3] Univ Brunei Darussalam, Fac Sci, Gadong 1410, BE, Brunei

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 21期

关键词：

Phenanthroline; 1,3,4-Oxadiazole; 1,3,4-Thiadiazole; SOLID-PHASE SYNTHESIS; REAGENT-BASED CYCLIZATION; BIOLOGICAL-ACTIVITY; DERIVATIVES; POTENT; THIOSEMICARBAZIDES; 1,2,4-TRIAZOLE; HETEROCYCLES; ANTITUMOR; ACID;

D O I：

10.1016/j.tetlet.2014.04.046

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New methods for the synthesis of 1,3,4-oxadiazole and 1,3,4-thiadiazole have been described. No cyclizations took place in the absence of ZnCl2. 1,3,4-Thiadiazoles are formed in the presence of ZnCl2 alone, whereas oxadiazoles are produced when a base such as Et3N or KOH was used along with ZnCl2. % Yields are optimized. (C) 2014 Elsevier Ltd. All rights reserved.

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页码：3267 / 3273

页数：7

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