Improving the translation of analgesic drugs to the clinic: animal models of neuropathic pain

被引:148
作者
du Sert, N. Percie [1 ]
Rice, A. S. C. [2 ,3 ]
机构
[1] Natl Ctr Replacement Refinement & Reduct Anim Res, London, England
[2] Univ London Imperial Coll Sci Technol & Med, Dept Surg & Canc, London, England
[3] Chelsea & Westminster Hosp NHS Fdn Trust, London, England
关键词
animal model; translation; neuropathic pain; analgesic; preclinical model; PERIPHERAL-NERVE INJURY; IN-VIVO EXPERIMENTS; POSTHERPETIC NEURALGIA; RODENT MODELS; RAT MODEL; PHARMACOLOGICAL MANAGEMENT; PREDICTIVE-VALIDITY; BURROWING BEHAVIOR; GRIMACE SCALE; GABAPENTIN;
D O I
10.1111/bph.12645
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Neuropathic pain remains an area of considerable unmet clinical need. Research based on preclinical animal models has failed to deliver truly novel treatment options, questioning the predictive value of these models. This review addresses the shortcomings of rodent in vivo models commonly used in the field and highlights approaches which could increase their predictivity, including more clinically relevant assays, outcome measures and animal characteristics. The methodological quality of animal studies also needs to be improved. Low internal validity and incomplete reporting lead to a waste of valuable research resources and animal lives, and ultimately prevent an objective assessment of the true predictivity of in vivo models.
引用
收藏
页码:2951 / 2963
页数:13
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