Stereoselective total synthesis of a novel regiomer of herbarumin I and its cytotoxic and antimicrobial activities

被引：10

作者：

Jangili, Paramesh ^{[1
]}

Kashanna, Jajula ^{[1
]}

Kumar, C. Ganesh ^{[2
]}

Poornachandra, Y. ^{[2
]}

Das, Biswanath ^{[1
]}

机构：

[1] Indian Inst Chem Technol, CSIR, Nat Prod Chem Div, Hyderabad 500607, Andhra Pradesh, India

[2] Indian Inst Chem Technol, CSIR, Biol Chem Lab, Hyderabad 500607, Andhra Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2014年 / 24卷 / 01期

关键词：

Herbarumin I; Regiomer; Total synthesis; Cytotoxicity; Antimicrobial activity; ACIDS; MACROLIDES;

D O I：

10.1016/j.bmcl.2013.11.010

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Stereoselective synthesis of a novel regiomer of the natural nonenolide, herbarumin I has been accomplished. The synthesis involves the coupling of the alcohol and acid fragments of the molecule using Yamaguchi protocol followed by intramolecular ring closing metathesis. The cytotoxic and antimicrobial properties of the synthetic regiomer have been studied. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：325 / 327

页数：3

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