Genes and SNPs in the pathway of immune response and caries risk: a systematic review and meta-analysis

被引：12

作者：

Chisini, Luiz Alexandre ^{[1
,2
]}

Cademartori, Mariana Gonzalez ^{[3
]}

Muniz Conde, Marucs Cristian ^{[1
]}

Costa, Francine Dos Santos ^{[1
]}

Tovo-Rodrigues, Luciana ^{[4
]}

de Carvalho, Rodrigo Varella ^{[5
]}

Demarco, Flavio Fernando ^{[2
]}

Correa, Marcos Britto ^{[2
]}

机构：

[1] Univ Vale Taquari, Biol Sci & Hlth Ctr, Lajeado, Brazil

[2] Univ Fed Pelotas, Dept Restorat Dent, Pelotas, RS, Brazil

[3] Univ Fed Pelotas, Dept Social & Prevent Dent, Pelotas, RS, Brazil

[4] Univ Fed Pelotas, Dept Epidemiol, Pelotas, RS, Brazil

[5] Fac Merid IMED, Dept Restorat Dent, Passo Fundo, RS, Brazil

来源：

BIOFOULING | 2020年 / 36卷 / 09期

关键词：

Cariogenic; genetics; immune system; oral habits; DMFT; DENTAL-CARIES; PROMOTER REGION; GLOBAL BURDEN; ASSOCIATION; POLYMORPHISMS; SUSCEPTIBILITY; PERIODONTITIS; LACTOFERRIN; EXPERIENCE; CHILDREN;

D O I：

10.1080/08927014.2020.1856821

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The aim of this systematic review and meta-analysis was to pool the data on Single Nucleotide Polymorphisms (SNPs) in immune response genes associated with dental caries. Nineteen studies were included in the review and 18 in the meta-analysis. Twenty-two SNPs were evaluated, which are linked to six different genes (MBL2, LFT, MASP2, DEFB1, FCN2 and MUC5B). Most SNPs (81.8%) are related to the possible functional impact on protein coding. The MBL2 gene was associated with caries experience in the analysis of the homozygote (OR = 2.12 CI95%[1.12-3.99]) and heterozygote (OR = 2.22 CI95%[1.44-3.44]) genotypes. The MUC5B gene was associated according to an analysis of the heterozygous genotype (OR = 1.83 CI95%[1.08-3.09]). Thus, SNPs related to immune response genes are linked to the phenotype of caries experience. Although the meta-analysis showed that the genes MBL2 and MUC5B were associated with caries, these results should be interpreted with caution due to the quality of the evidence.

引用

页码：1100 / 1116

页数：17

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