Increased risk of lung cancer among patients with bronchiectasis: a nationwide cohort study

被引:26
作者
Chung, W. -S. [1 ,2 ,3 ]
Lin, C. -L. [4 ,5 ]
Hsu, W. -H. [6 ,7 ,8 ]
Kao, C. -H. [7 ,8 ,9 ,10 ]
机构
[1] Taichung Hosp, Minist Hlth & Welf, Dept Internal Med, Taichung, Taiwan
[2] China Med Univ, Dept Hlth Serv Adm, Taichung 404, Taiwan
[3] Cent Taiwan Univ Sci & Technol, Dept Healthcare Adm, Taichung, Taiwan
[4] China Med Univ Hosp, Management Off Hlth Data, Taichung, Taiwan
[5] China Med Univ, Coll Med, Taichung 404, Taiwan
[6] China Med Univ Hosp, Dept Resp & Crit Care, Taichung, Taiwan
[7] China Med Univ, Grad Inst Clin Med Sci, Coll Med, 2 Yuh Der Rd, Taichung 404, Taiwan
[8] China Med Univ, Sch Med, Coll Med, 2 Yuh Der Rd, Taichung 404, Taiwan
[9] China Med Univ Hosp, Dept Nucl Med, Taichung, Taiwan
[10] China Med Univ Hosp, PET Ctr, Taichung, Taiwan
关键词
OBSTRUCTIVE PULMONARY-DISEASE; HELICOBACTER-PYLORI INFECTION; FACTOR-KAPPA-B; POPULATION; SMOKING; INFLAMMATION; TAIWAN; TUBERCULOSIS; ASSOCIATION; PROGRESSION;
D O I
10.1093/qjmed/hcu237
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Methods: This study investigated the incidence and risk for lung cancer in 57 576 patients newly hospitalized with bronchiectasis between 1998 and 2010 from the Taiwan National Health Insurance Research Database. The comparison cohort comprised 230 304 individuals from the general population without bronchiectasis. The follow-up period was from the time of the initial hospitalization for bronchiectasis to the date of a lung cancer diagnosis, censoring, or 31 December 2011. We used Cox proportional hazard regression models to analyse the risk of lung cancer by including the variables of sex, age and comorbidities. Results: The incidence of lung cancer was higher in patients with bronchiectasis than in the comparison cohort (4.58 vs. 2.02 per 1000 person-years). The bronchiectasis patients exhibited a 2.36-fold increased risk of lung cancer compared with the comparison cohort after adjustment for age, sex and comorbidities (adjusted hazard ratio [aHR] = 2.36, 95% confidence interval [CI] = 2.19-2.55). The sex-specific bronchiectasis cohort to comparison cohort revealed that the aHR was 2.41 (95% CI = 2.11-2.76) for the women and 2.33 (95% CI = 2.12-2.56) for the men. The incidence rate of lung cancer increased as age increased in both cohorts. Conclusion: This nationwide study determined that the patients with bronchiectasis exhibited an increased risk of lung cancer compared with the general population.
引用
收藏
页码:17 / 25
页数:9
相关论文
共 50 条
[1]   Bronchiectasis and the risk of cancer: a nationwide retrospective cohort study [J].
Chung, W. -S. ;
Lin, C. -L. ;
Lin, C. -L. ;
Kao, C. -H. .
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2015, 69 (06) :682-688
[2]   Increased Lung Cancer Risk Among Patients with Pneumococcal Pneumonia: A Nationwide Population-Based Cohort Study [J].
Lin, Te-Yu ;
Huang, Wen-Yen ;
Lin, Jung-Chung ;
Lin, Cheng-Li ;
Sung, Fung-Chang ;
Kao, Chia-Hung ;
Yeh, Jun-Jun .
LUNG, 2014, 192 (01) :159-165
[3]   Increased risk of lung cancer in patients with eczema: a nationwide cohort study in Taiwan [J].
Juan, Chao-Kuei ;
Shen, Jui-Lung ;
Lin, Cheng-Li ;
Kim, Karen Wang ;
Chen, Wen-Chi .
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, 2016, 14 (09) :924-931
[4]   Increased risk of lung cancer in individuals with preserved ratio impaired spirometry: a nationwide cohort study [J].
Kim, Taeyun ;
Choe, Junsu ;
Im, Yunjoo ;
Heo, Jihye ;
Park, Hye Yun ;
Kang, Danbee ;
Shin, Sun Hye .
SCIENTIFIC REPORTS, 2025, 15 (01)
[5]   Increased risk of cancer among 3663 patients with cutaneous lupus erythematosus: a Swedish nationwide cohort study [J].
Gronhagen, C. M. ;
Fored, C. M. ;
Granath, F. ;
Nyberg, F. .
BRITISH JOURNAL OF DERMATOLOGY, 2012, 166 (05) :1053-1059
[6]   Bronchiectasis and increased risk of ischemic stroke: a nationwide population-based cohort study [J].
Chen, Yung-Fu ;
Lin, Hsuan-Hung ;
Lin, Chih-Sheng ;
Turbat, Battsetseg ;
Wang, Kuo-An ;
Chung, Wei-Sheng .
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 2017, 12 :1375-1383
[7]   Increased Lung Cancer Risk among Patients with Pulmonary Tuberculosis A Population Cohort Study [J].
Yu, Yang-Hao ;
Liao, Chien-Chang ;
Hsu, Wu-Huei ;
Chen, Hung-Jen ;
Liao, Wei-Chih ;
Muo, Chih-Hsin ;
Sung, Fung-Chang ;
Chen, Chih-Yi .
JOURNAL OF THORACIC ONCOLOGY, 2011, 6 (01) :32-37
[8]   Cancer risk among gingivitis and periodontitis patients: a nationwide cohort study [J].
Wen, B. -W. ;
Tsai, C. -S. ;
Lin, C. -L. ;
Chang, Y. -J. ;
Lee, C. -F. ;
Hsu, C. -H. ;
Kao, C. -H. .
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, 2014, 107 (04) :283-290
[9]   Cancer risk in patients with cholelithiasis and after cholecystectomy: a nationwide cohort study [J].
Chen, Yen-Kung ;
Yeh, Jiann-Horng ;
Lin, Cheng-Li ;
Peng, Chiao-Ling ;
Sung, Fung-Chang ;
Hwang, Ing-Ming ;
Kao, Chia-Hung .
JOURNAL OF GASTROENTEROLOGY, 2014, 49 (05) :923-931
[10]   Increased risk of Bell palsy in patients with migraine A nationwide cohort study [J].
Peng, Kuan-Po ;
Chen, Yung-Tai ;
Fuh, Jong-Ling ;
Tang, Chao-Hsiun ;
Wang, Shuu-Jiun .
NEUROLOGY, 2015, 84 (02) :116-124