Plasma Caffeine Levels and Risk of Alzheimer's Disease and Parkinson's Disease: Mendelian Randomization Study

被引：37

作者：

Larsson, Susanna C. ^{[1
,2
]}

Woolf, Benjamin ^{[3
,4
,5
]}

Gill, Dipender ^{[6
,7
,8
]}

机构：

[1] Uppsala Univ, Dept Surg Sci, Unit Med Epidemiol, SE-75185 Uppsala, Sweden

[2] Karolinska Inst, Unit Cardiovasc & Nutr Epidemiol, Inst Environm Med, SE-17177 Stockholm, Sweden

[3] Univ Bristol, MRC Integrat Epidemiol Unit, Bristol BS8 2BN, Avon, England

[4] Univ Bristol, Sch Psychol Sci, Bristol BS8 1TU, Avon, England

[5] London Sch Hyg & Trop Med, Fac Epidemiol & Populat Hlth, London WC1E 7HT, England

[6] Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London W2 1NY, England

[7] St Georges Univ London, Inst Infect & Immun, Dept Clin Pharmacol & Therapeut, London SW17 0RE, England

[8] Novo Nordisk Res Ctr Oxford, Genet Dept, Old Rd Campus, Oxford OX3 7FZ, England

来源：

NUTRIENTS | 2022年 / 14卷 / 09期

基金：

英国经济与社会研究理事会; 瑞典研究理事会;

关键词：

Alzheimer's disease; caffeine; coffee; Mendelian randomization; Parkinson's disease; COFFEE CONSUMPTION; METAANALYSIS; IDENTIFICATION; LOCI;

D O I：

10.3390/nu14091697

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

We leveraged genetic variants associated with caffeine metabolism in the two-sample Mendelian randomization framework to investigate the effect of plasma caffeine levels on the risk of Alzheimer's disease and Parkinson's disease. Genetic association estimates for the outcomes were obtained from the International Genomics of Alzheimer's Project, the International Parkinson's Disease Genomics consortium, the FinnGen consortium, and the UK Biobank. Genetically predicted higher plasma caffeine levels were associated with a non-significant lower risk of Alzheimer's disease (odds ratio 0.87; 95% confidence interval 0.76, 1.00; p = 0.056). A suggestive association was observed for genetically predicted higher plasma caffeine levels and lower risk of Parkinson's disease in the FinnGen consortium. but not in the International Parkinson's Disease Genomics consortium; no overall association was found (odds ratio 0.92; 95% confidence interval 0.77, 1.10; p = 0.347). This study found possible suggestive evidence of a protective role of caffeine in Alzheimer's disease. The association between caffeine and Parkinson's disease requires further study.

引用

页数：5

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