Impact of allergic rhinitis on the day-to-day lives of children: insights from an Australian cross-sectional study

被引：20

作者：

Bosnic-Anticevich, Sinthia ^{[1
]}

Smith, Peter ^{[2
]}

Abramson, Michael ^{[3
,4
]}

Hespe, Charlotte Mary ^{[5
,6
,7
]}

Johnson, Menai ^{[8
]}

Stosic, Rodney ^{[9
]}

Price, David B. ^{[10
,11
]}

机构：

[1] Univ Sydney, Sydney Local Hlth Dist, Woolcock Inst Med Res, Qual Use Med Grp, Sydney, NSW, Australia

[2] Griffith Univ, Clin Med, Southport, Qld, Australia

[3] Monash Univ, Sch Publ Hlth & Prevent Med, Clin Epidemiol, Melbourne, Vic, Australia

[4] Alfred Hosp, Resp Med, Melbourne, Vic, Australia

[5] Univ Notre Dame, Primary Care Res, Sydney, NSW, Australia

[6] Sydney Sch Med, Sydney, NSW, Australia

[7] Asthma Fdn, Sydney, NSW, Australia

[8] Sanofi Australia New Zealand, Real World Clin Evidence, Cent Med Operat, Sydney, NSW, Australia

[9] Sanofi Consumer Healthcare, Med Affairs, Sydney, NSW, Australia

[10] Observat & Pragmat Res Inst, Singapore, Singapore

[11] Univ Aberdeen, Div Appl Hlth Sci, Ctr Acad Primary Care, Aberdeen, Scotland

来源：

BMJ OPEN | 2020年 / 10卷 / 11期

关键词：

allergy; paediatric thoracic medicine; quality in health care; QUALITY-OF-LIFE; VISUAL ANALOG SCALE; MASK-RHINITIS; ASTHMA; POPULATION; PREVALENCE; RHINOCONJUNCTIVITIS; ADOLESCENTS; VALIDATION; MANAGEMENT;

D O I：

10.1136/bmjopen-2020-038870

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Study design and objectiveCross-sectional, observational survey to describe the impact of allergic rhinitis (AR) on Australian children (2 to 15 years).MethodsParticipants (n=1541), parents of children aged 2 to 15 years, provided information on behalf of themselves and one eligible child in their household using a custom-built online questionnaire. Children were allocated to case (AR) or control (No AR) analysis groups based on a validated screening questionnaire.Statistical methodsThe study sample was stratified on age: primary analysis population (6 to 15 years, n=1111; AR=797, No AR=314); exploratory population (2 to 5 years). The primary endpoint, parent-perceived burden, was quantified using a validated measure of health status and analysed via comparison of means.ResultsThe majority of AR cases were treated (730/797; 90.3%) and classified as having moderate-severe, intermittent AR (549/797; 68.9%). Half reported adequate symptom control in the prior 2 weeks (389/797; 48.8%; OR=4.04; 95% CI (CI) 2.24 to 7.31). Having AR was associated with worse overall health status (7.4 vs 8.4, mean difference (least squares mean difference (LSMD))=-0.99; 95% CI -1.18 to -0.79), fewer days being happy (22.2 vs 25.9, LSMD=-3.68; 95% CI -4.82 to -2.54) and more days of poor physical (2.82 vs 0.78, LSMD=2.04; 95% CI 1.61 to 2.47) and emotional (2.14 vs 0.67, LSMD=1.47; 95% CI 1.02 to -1.92) health compared with not having AR. All of these outcomes were significantly (p<0.05) worse in children who reported inadequate symptom control. Having AR negatively impacted on schoolwork, sleep and other activities, and increased the likelihood of having comorbidities.ConclusionThe parent-perceived burden of AR in Australian children is high and it impacts many areas of day-to-day living. Inadequate symptom control is a key driver of the extent of this impact. Opportunities to optimise the management of AR in children include the adoption of self-assessment tools to gauge and monitor adequacy of symptom control.

引用

页数：12

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