Myeloid Differentiation Primary Response Protein 88 (MyD88): The Central Hub of TLR/IL-1R Signaling

被引：108

作者：

Chen, Lingfeng ^{[1
,2
,3
]}

Zheng, Lulu ^{[4
]}

Chen, Pengqin ^{[1
]}

Liang, Guang ^{[1
,3
]}

机构：

[1] Wenzhou Med Univ, Chem Biol Res Ctr, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China

[2] Wenzhou Med Univ, Dept Intens Care Unit, Affiliated Hosp 1, Wenzhou 325035, Zhejiang, Peoples R China

[3] Univ Chinese Acad Sci, Wenzhou Inst, Wenzhou 325001, Zhejiang, Peoples R China

[4] Tongde Hosp Zhejiang Prov, Dept Pharm, Hangzhou 310000, Zhejiang, Peoples R China

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2020年 / 63卷 / 22期

基金：

中国国家自然科学基金;

关键词：

NF-KAPPA-B; TIR-DOMAIN; CRYSTAL-STRUCTURE; STRUCTURAL BASIS; INFLAMMATORY RESPONSES; MYD88-DEFICIENT MICE; ADAPTER MOLECULES; RATIONAL DESIGN; RECEPTOR DOMAIN; CRYO-EM;

D O I：

10.1021/acs.jmedchem.0c00884

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Myeloid differentiation primary response protein 88 (MyD88) is a ubiquitously expressed cytoplasmic adaptor protein that plays a central role in the Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) signaling pathways. TLR/IL-1R pathways regulate the proliferation and differentiation of cells involved in the innate and adaptive immunity. Although the general TLR/IL-1R activation cascade is well understood, the molecular mechanisms involving MyD88 have only begun to surface in the past decade. In this review, we explore MyD88 structural biology, the role of posttranslational modifications (PTMs), and the recent developments in MyD88 inhibitor discovery and use. We also highlight the potential application of MyD88-targeted therapies in human diseases.

引用

页码：13316 / 13329

页数：14

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