Pyruvate kinase M2 and cancer: an updated assessment

被引：153
|
作者：
Iqbal, Mohd Askandar [1 ]
Gupta, Vibhor [1 ]
Gopinath, Prakasam [1 ]
Mazurek, Sybille [2 ]
Bamezai, Rameshwar N. K. [1 ]
机构：
[1] Jawaharlal Nehru Univ, Sch Life Sci, Natl Ctr Appl Human Genet, New Delhi 110067, India
[2] Univ Giessen, Inst Vet Physiol & Biochem, D-35392 Giessen, Germany
来源：
FEBS LETTERS | 2014年 / 588卷 / 16期
关键词：
PKM2; Cancer metabolism; Warburg effect; POSITRON-EMISSION-TOMOGRAPHY; HYPOXIA-INDUCIBLE FACTOR-1; ISOENZYME TYPE M2; TUMOR-GROWTH; AEROBIC GLYCOLYSIS; GLUCOSE-METABOLISM; COLORECTAL-CANCER; PROTEIN-KINASE; NUCLEAR TRANSLOCATION; GENE-TRANSCRIPTION;
D O I：
10.1016/j.febslet.2014.04.011
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cancer cells are characterized by high glycolytic rates to support energy regeneration and anabolic metabolism, along with the expression of pyruvate kinase isoenzyme M2 (PKM2). The latter catalyzes the last step of glycolysis and reprograms the glycolytic flux to feed the special metabolic demands of proliferating cells. Besides, PKM2 has moonlight functions, such as gene transcription, favoring cancer. Accumulating evidence suggests a critical role played by the low-activity-dimeric PKM2 in tumor progression, supported by the identification of mutations which result in the down-regulation of its activity and tumorigenesis in a nude mouse model. This review discusses PKM2 regulation and the benefits it confers to cancer cells. Further, conflicting views on PKM2's role in cancer, its therapeutic relevance and future directions in the field are also discussed. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：2685 / 2692
页数：8
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