Determination and correlation of the solubility and thermodynamic parameters of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside in pure organic solvents

被引：4

作者：

Huang, Yanru ^{[1
]}

Lan, Ting ^{[1
]}

Zhang, Junna ^{[1
]}

Luo, Min ^{[1
]}

He, Wei ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Sch Pharm, Dept Chem, Xian 710032, Shaanxi, Peoples R China

来源：

JOURNAL OF MOLECULAR LIQUIDS | 2018年 / 256卷

关键词：

2,3,5,4'-retrahydroxystilbene-2-O-beta-D-gluco-side; Solubility; Thermodynamic models; Dissolution enthalpy; MAGNESIUM-DL-ASPARTATE; P-TOLUIC ACID; POLYGONUM-MULTIFLORUM; 313.15; K; STILBENE GLYCOSIDE; TEMPERATURES; WATER; MIXTURES; 2,3,4',5-TETRAHYDROXYSTILBENE-2-O-BETA-D-GLUCOSIDE; TOXICITY;

D O I：

10.1016/j.molliq.2018.02.046

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The solubility of 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside (THSG) was measured in nine organic solvents (methanol, ethanol, n-propanol, i-propanol, ethyl acetate, acetone, acetonitrile, N,N-dimethylformamide (DMF), and tetrahydrofuran (THF)) in the temperature range 278.15 to 318.15 K at atmosphere pressure by the gravimetrical method. In the temperature range considered, the solubility of THSG in all of the solvents increases with increasing temperature. At a given temperature, the solubility of THSG in the different solvents is in the order DMF > THF > acetone > methanol > ethanol > n-propanol > i-propanol > ethyl acetate > acetonitrile. The solubility data of THSG are well correlated with the modified Apelblat equation, Buchowski-Ksiaiczak lambda h equation, and Van't Hoff equation. The correlation shows good agreement with the experimental results, and the largest values of the relative average deviation and root-mean-square deviation are 2.37 x 10(-2) and 4.53 x 10(-4), respectively. The apparent dissolution enthalpy and excess enthalpy of the solutions were also investigated. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：344 / 351

页数：8

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