Osseous tissue reaction around hydroxyapatite block implanted into proximal metaphysis of tibia of rat with collagen-induced arthritis

被引:19
作者
Okazaki, A [1 ]
Koshino, T [1 ]
Saito, T [1 ]
Takagi, T [1 ]
机构
[1] Yokohama City Univ, Sch Med, Dept Orthopaed Surg, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan
关键词
hydroxyapatite block; osteogenesis; collagen-induced arthritis; osteoporosis;
D O I
10.1016/S0142-9612(99)00198-2
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
This study was conducted to investigate the influence of osteoporosis on new bent: formation around a hydroxyapatite (HA) block implanted into the proximal metaphysis of the tibia of rats with collagen-induced arthritis (CIA). Ten rats were immunized with an emulsion of bovine type II collagen and Freund's complete adjuvant (arthritis group). Another 10 rats, which were not immunized were used as the control group. Seventeen days after immunization, HA block was implanted into the proximal metaphysis of the tibia. Four weeks after implantation, all rats were killed. The serum level of tetrate-resistant acid phosphatase (TRAP), bone mineral density (BMD) in the proximal metaphysis of the tibia and the affinity index in the arthritis group were 28.0 +/- 3.5 IU/ml, 130.3 +/- 28.7mg/cm(2) and 77.6 +/- 10.8%, respectively, and those in the control group were 24.6 +/- 5.5 IU/ml, 175.9 +/- 30.5 mg/cm(2) and 56.3 +/- 14.8%. The serum level of TRAP was higher (P < 0.05) and BMD was lower (P < 0.005) in the arthritis group. The amount of new bone formation around the HA block was larger (affinity index, P < 0.05) in the arthritis group than in the control group. These findings suggest that bone formation around HA block might be enhanced even in conditions associated with highly activated bone resorption and bone formation, such as arthritis. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:483 / 487
页数:5
相关论文
共 12 条
  • [1] Cedric M., 1982, CALCIFIED TISSUE INT, V34, P285
  • [2] REMODELING OF BONE AROUND HYDROXYAPATITE AND TITANIUM IN EXPERIMENTAL OSTEOPOROSIS
    HAYASHI, K
    UENOYAMA, K
    MASHIMA, T
    SUGIOKA, Y
    [J]. BIOMATERIALS, 1994, 15 (01) : 11 - 16
  • [3] REEVALUATION OF THE BIOCOMPATIBILITY OF BIOINERT CERAMICS INVIVO
    HAYASHI, K
    MATSUGUCHI, N
    UENOYAMA, K
    SUGIOKA, Y
    [J]. BIOMATERIALS, 1992, 13 (04) : 195 - 200
  • [4] MECHANISMS OF BONE LOSS - RHEUMATOID-ARTHRITIS, PERIODONTAL-DISEASE AND OSTEOPOROSIS
    HAYWARD, M
    FIEDLERNAGY, C
    [J]. AGENTS AND ACTIONS, 1987, 22 (3-4): : 251 - 254
  • [5] INVOLVEMENT OF INTERLEUKIN-1-LIKE FACTOR(S) IN TYPE-II COLLAGEN-INDUCED ARTHRITIS IN MICE
    KASAMA, T
    KOBAYASHI, K
    KANEMITSU, H
    NAKATANI, K
    KAGA, S
    YAMAGATA, N
    NEGISHI, M
    IDE, H
    TAKAHASHI, T
    NIWA, Y
    [J]. IMMUNOLOGY LETTERS, 1990, 26 (02) : 171 - 175
  • [6] KIM B, 1989, CALCIFIED TISSUE INT, V44, P99
  • [7] BONE-FORMATION AS A REACTION TO HYDRAULIC HYDROXYAPATITE THERMAL-DECOMPOSITION PRODUCT USED AS BONE-CEMENT IN RABBITS
    KOSHINO, T
    KUBOTA, W
    MORII, T
    [J]. BIOMATERIALS, 1995, 16 (02) : 125 - 128
  • [8] KUBOTA W, 1992, Journal of the Japanese Orthopaedic Association, V66, P110
  • [9] PHILIP S, 1987, J BONE MINER RES, V2, P559
  • [10] QUANTITATIVE HISTOLOGIC-STUDIES ON THE PATHOGENESIS OF PERIARTICULAR OSTEOPOROSIS IN RHEUMATOID-ARTHRITIS
    SHIMIZU, S
    SHIOZAWA, S
    SHIOZAWA, K
    IMURA, S
    FUJITA, T
    [J]. ARTHRITIS AND RHEUMATISM, 1985, 28 (01): : 25 - 31