RETRACTED: MiR-125b Inhibits LPS-Induced Inflammatory Injury via Targeting MIP-1α in Chondrogenic Cell ATDC5 (Retracted Article)

被引:22
|
作者
Jia, Jinling [1 ]
Wang, Jingyu [1 ]
Zhang, Junlei [2 ]
Cui, Mingxing [1 ]
Sun, Xiaohui [1 ]
Li, Qingjiang [1 ]
Zhao, Bin [1 ]
机构
[1] Xinxiang Med Univ, Affiliated Hosp 1, Orthoped Surg Ward 2, 88 Jiankang Rd, Xinxiang 453100, Peoples R China
[2] Xinxiang Med Univ, Affiliated Hosp 1, Orthoped Surg Ward 4, Xinxiang, Peoples R China
关键词
Osteoarthritis; MicroRNA-125b; Inflammatory injury; Macrophage inflammatory protein-1 alpha; NF-kappa B/JNK signaling pathways; IL-1-BETA-INDUCED CHONDROCYTE APOPTOSIS; DOWN-REGULATION; OSTEOARTHRITIS; EXPRESSION; MICRORNAS; GENE; PROLIFERATION; ACTIVATION; MIGRATION; CARTILAGE;
D O I
10.1159/000488178
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Background/Aims: Chondrocyte apoptosis is largely responsible for cartilage degeneration in osteoarthritis (OA). MicroRNAs (miRNAs) play an important role in chondrogenesis and cartilage remodeling. This study explored the effect of miR-125b on inflammatory injury in chondrogenic cells. Methods: LPS was used to simulate inflammatory injury in murine chondrogenic ATDC5 cell lines. Targeting effect of miR-125b on MIP-1 alpha 3'UTR was assessed by dual luciferase activity assay. Regulatory effect of miR-125b on MIP-1 alpha expression and the potential regulatory mechanism on inflammatory injury were assessed by Western blot. Results: miR-125b expression was decreased in LPS-induced ATDC5 cells and overexpression of miR-125b inhibited LPS-induced cell viability decline, the rise of apoptosis and inflammatory factors' productions. MIP-1 alpha expression was negatively related to miR-125b, and miR-125b directly targeted with 3'UTR of MIP-1 alpha. Knockdown of miR-125b promoted LPS-induced inflammatory response via upregulation of MIP-1 alpha. miR-125b expression in LPS-induced ATDC5 cells was negatively related with activations of NF-kappa B and JNK signaling pathways. Overexpression of miR-125b inhibited LPS-induced inflammation injury via suppressing MIP-1 alpha expression and inhibiting activations of NF-kappa B and JNK signaling pathways. Conclusion: miR-125b could play an important role in inflammatory injury of chondrogenic cells and miR-125b affected inflammatory injury of ATDC5 cells via regulating expression of MIP-1 alpha and regulating NF-kappa B and JNK signaling pathways. (C) 2018 The Author(s) Published by S. Karger AG, Basel
引用
收藏
页码:2305 / 2316
页数:12
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