Pharmacokinetic study of long-acting oxytetracycline in cows

被引：0

作者：

SanMartin, B ^{[1
]}

Lagos, R ^{[1
]}

Gai, MN ^{[1
]}

机构：

[1] UNIV CHILE,FAC CIENCIAS QUIM & FARMACEUT,LAB CIENCIAS & TECNOL FARMACEUT,SANTIAGO,CHILE

来源：

ARCHIVOS DE MEDICINA VETERINARIA | 1996年 / 28卷 / 02期

关键词：

pharmacokinetics; oxytetracycline; long-acting;

D O I：

暂无

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Pharmacokinetics of a long-acting formula of oxytetracycline (OTC) in one formulation of dymetylacetomide, was studied in seven cows after i.m. administration (20 mg/kg of body weight). Serum OTC concentration was measured using a microbiological assay procedure with a sensibility of 0.312 mu g/ml. The mean residence time (MRT) was 20.68+/-5.55 h and the half life was 9.63+/-4.04 h. The maximal OTC concentration (7.53+/-2.20 mu g/ml) was observed after 8.42+/-3.43 h. Serum concentration >1 mu g/ml was maintained for about 39.57+/-13.15 hours.

引用

页码：19 / 25

页数：7

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