The Anopheles Innate Immune System in the Defense against Malaria Infection

被引：128
作者：
Clayton, April M. [1 ]
Dong, Yuemei [1 ]
Dimopoulos, George [1 ]
机构：
[1] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, W Harry Feinstone Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA
来源：
JOURNAL OF INNATE IMMUNITY | 2014年 / 6卷 / 02期
基金：
美国国家卫生研究院;
关键词：
Anopheles; Innate immunity; Plasmodium; Malaria; Mosquito; QUANTITATIVE TRAIT LOCI; COMPLEMENT-LIKE PROTEIN; MIDGUT EPITHELIAL RESPONSES; FIBRINOGEN-RELATED PROTEINS; MOSQUITO AEDES-AEGYPTI; PLASMODIUM-FALCIPARUM; TIME BOMB; OOKINETE INVASION; MOLECULAR-INTERACTIONS; BACTERIAL CHALLENGE;
D O I：
10.1159/000353602
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The multifaceted innate immune system of insects is capable of fighting infection by a variety of pathogens including those causing human malaria. Malaria transmission by the Anopheles mosquito depends on the Plasmodium parasite's successful completion of its lifecycle in the insect vector, a process that involves interactions with several tissues and cell types as well as with the mosquito's innate immune system. This review will discuss our current understanding of the Anopheles mosquito's innate immune responses against the malaria parasite Plasmodium and the influence of the insect's intestinal microbiota on parasite infection. Copyright (C) 2013 S. Karger AG, Basel
引用
收藏
页码：169 / 181
页数：13
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