Role of sirtuins in ischemia-reperfusion injury

被引:55
作者
Pantazi, Eirini [1 ]
Amine Zaouali, Mohamed [1 ]
Bejaoui, Mohamed [1 ]
Folch-Puy, Emma [1 ]
Ben Abdennebi, Hassen [2 ]
Rosello-Catafau, Joan [3 ]
机构
[1] Spanish Natl Res Council, Inst Biomed Res Barcelona, Expt Hepat Ischemia Reperfus Unit, Barcelona 08036, Catalonia, Spain
[2] Fac Pharm, Mol Biol & Anthropol Appl Dev & Hlth UR12ES11, Monastir 5000, Tunisia
[3] Spanish Natl Res Council, Inst Biomed Res Barcelona, Dept Expt Pathol, Barcelona 08036, Catalonia, Spain
关键词
sirtuin; 1; 3; ischemia-reperfusion injury; oxidative stress; apoptosis; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; PERMEABILITY TRANSITION PORE; REGULATOR; PROTECTS; MEDIATED CELL-DEATH; OXIDATIVE STRESS; UNCOUPLING PROTEIN-2; MOLECULAR-MECHANISMS; ISCHEMIA/REPERFUSION INJURY; KIDNEY-TRANSPLANTATION; GLUCOSE-HOMEOSTASIS;
D O I
10.3748/wjg.v19.i43.7594
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Ischemia-reperfusion injury (IRI) remains an unresolved and complicated situation in clinical practice, especially in the case of organ transplantation. Several factors contribute to its complexity; the depletion of energy during ischemia and the induction of oxidative stress during reperfusion initiate a cascade of pathways that lead to cell death and finally to severe organ injury. Recently, the sirtuin family of nicotinamide adenine dinucleotide-dependent deacetylases has gained increasing attention from researchers, due to their involvement in the modulation of a wide variety of cellular functions. There are seven mammalian sirtuins and, among them, the nuclear/cytoplasmic sirtuin 1 (SIRT1) and the mitochondrial sirtuin 3 (SIRT3) are ubiquitously expressed in many tissue types. Sirtuins are known to play major roles in protecting against cellular stress and in controlling metabolic pathways, which are key processes during IRI. In this review, we mainly focus on SIRT1 and SIRT3 and examine their role in modulating pathways against energy depletion during ischemia and their involvement in oxidative stress, apoptosis, microcirculatory stress and inflammation during reperfusion. We present evidence of the beneficial effects of sirtuins against IRI and emphasize the importance of developing new strategies by enhancing their action. (C) 2013 Baishideng Publishing Group Co., Limited. All rights reserved.
引用
收藏
页码:7594 / 7602
页数:9
相关论文
共 101 条
[1]   Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase [J].
Ahuja, Nidhi ;
Schwer, Bjoern ;
Carobbio, Stefania ;
Waltregny, David ;
North, Brian J. ;
Castronovo, Vincenzo ;
Maechler, Pierre ;
Verdin, Eric .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (46) :33583-33592
[2]   The Brain: A New Organ for the Metabolic Actions of SIRT1 [J].
Al Massadi, O. ;
Quinones, M. ;
Lear, P. ;
Dieguez, C. ;
Nogueiras, R. .
HORMONE AND METABOLIC RESEARCH, 2013, 45 (13) :960-966
[3]   Sirt1 regulates aging and resistance to oxidative stress in the heart [J].
Alcendor, Ralph R. ;
Gao, Shumin ;
Zhai, Peiyong ;
Zablocki, Daniela ;
Holle, Eric ;
Yu, Xianzhong ;
Tian, Bin ;
Wagner, Thomas ;
Vatner, Stephen F. ;
Sadoshima, Junichi .
CIRCULATION RESEARCH, 2007, 100 (10) :1512-1521
[4]   SIRT3 is pro-apoptotic and participates in distinct basal apoptotic pathways [J].
Allison, Simon J. ;
Milner, Jo .
CELL CYCLE, 2007, 6 (21) :2669-2677
[5]  
Andrews DT, 2012, ANAESTH INTENS CARE, V40, P46
[6]   Resveratrol prevents antibody-induced apoptotic death of retinal cells through upregulation of Sirt1 and Ku70 [J].
Anekonda T.S. ;
Adamus G. .
BMC Research Notes, 1 (1)
[7]   SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production [J].
Bell, E. L. ;
Emerling, B. M. ;
Ricoult, S. J. H. ;
Guarente, L. .
ONCOGENE, 2011, 30 (26) :2986-2996
[8]   Uncoupling protein 2 modulates cell viability in adult rat cardiomyocytes [J].
Bodyak, Natalya ;
Rigor, Debra L. ;
Chen, Yee-Shiuan ;
Han, Yuchi ;
Bisping, Egbert ;
Pu, William T. ;
Kang, Peter M. .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2007, 293 (01) :H829-H835
[9]   SIRT1 transgenic mice show phenotypes resembling calorie restriction [J].
Bordone, Laura ;
Cohen, Dena ;
Robinson, Ashley ;
Motta, Maria Carla ;
van Veen, Ed ;
Czopik, Agnieszka ;
Steele, Andrew D. ;
Crowe, Hayley ;
Marmor, Stephen ;
Luo, Jianyuan ;
Gu, Wei ;
Guarente, Leonard .
AGING CELL, 2007, 6 (06) :759-767
[10]   Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3 [J].
Brenmoehl, Julia ;
Hoeflich, Andreas .
MITOCHONDRION, 2013, 13 (06) :755-761