A linkage map of the rat genome derived from three F-2 crosses

被引：134

作者：

Bihoreau, MT

Gauguier, D

Kato, N

Hyne, G

Lindpaintner, K

Rapp, JP

James, MR

Lathrop, GM

机构：

[1] HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DEPT CARDIOL,BOSTON,MA 02115

[2] MED COLL OHIO,DEPT PHYSIOL & MOL MED,TOLEDO,OH 43699

来源：

GENOME RESEARCH | 1997年 / 7卷 / 05期

关键词：

D O I：

10.1101/gr.7.5.434

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report the construction of a dense linkage map of the rat genome integrating 767 simple sequence length polymorphism markers, combined over three crosses with high rates of polymorphism, F-2 populations from WKY x S (n = 159), BN x S (n = 91), and BN x GK (n = 139) were selected and genotyped for combinations of microsatellite markers. The loci define 21 linkage groups corresponding to the 20 rat autosomal chromosomes and the X chromosome. The map spans a genetic length of 1998 cM. This combined linkage map should facilitate the advancement of genetic studies for a wide variety of rat models characterized for complex phenotypes.

引用

页码：434 / 440

页数：7

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