A linkage map of the rat genome derived from three F-2 crosses

被引：134

作者：

Bihoreau, MT

Gauguier, D

Kato, N

Hyne, G

Lindpaintner, K

Rapp, JP

James, MR

Lathrop, GM

机构：

[1] HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DEPT CARDIOL,BOSTON,MA 02115

[2] MED COLL OHIO,DEPT PHYSIOL & MOL MED,TOLEDO,OH 43699

来源：

GENOME RESEARCH | 1997年 / 7卷 / 05期

关键词：

D O I：

10.1101/gr.7.5.434

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report the construction of a dense linkage map of the rat genome integrating 767 simple sequence length polymorphism markers, combined over three crosses with high rates of polymorphism, F-2 populations from WKY x S (n = 159), BN x S (n = 91), and BN x GK (n = 139) were selected and genotyped for combinations of microsatellite markers. The loci define 21 linkage groups corresponding to the 20 rat autosomal chromosomes and the X chromosome. The map spans a genetic length of 1998 cM. This combined linkage map should facilitate the advancement of genetic studies for a wide variety of rat models characterized for complex phenotypes.

引用

页码：434 / 440

页数：7

共 21 条

[1] Construction and characterization of a 10-genome equivalent yeast artificial chromosome library for the laboratory rat, Rattus norvegicus [J].

Cai, L ;

Schalkwyk, LC ;

SchoeberleinStehli, A ;

Zee, RYL ;

Smith, A ;

Haaf, T ;

Georges, M ;

Lehrach, H ;

Lindpaintner, K .

GENOMICS, 1997, 39 (03) :385-392

[2] A comprehensive genetic map of the human genome based on 5,264 microsatellites [J].

Dib, C ;

Faure, S ;

Fizames, C ;

Samson, D ;

Drouot, N ;

Vignal, A ;

Millasseau, P ;

Marc, S ;

Hazan, J ;

Seboun, E ;

Lathrop, M ;

Gyapay, G ;

Morissette, J ;

Weissenbach, J .

NATURE, 1996, 380 (6570) :152-154

[3] Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat [J].

Galli, J ;

Li, LS ;

Glaser, A ;

Ostenson, CG ;

Jiao, H ;

FakhraiRad, H ;

Jacob, HJ ;

Lander, ES ;

Luthman, H .

NATURE GENETICS, 1996, 12 (01) :31-37

[4] Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat [J].

Gauguier, D ;

Froguel, P ;

Parent, V ;

Bernard, C ;

Bihoreau, MT ;

Portha, B ;

James, MR ;

Penicaud, L ;

Lathrop, M ;

Ktorza, A .

NATURE GENETICS, 1996, 12 (01) :38-43

[5] Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1 [J].

Gu, LP ;

Dene, H ;

Deng, AY ;

Hoebee, B ;

Bihoreau, MT ;

James, M ;

Rapp, JP .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (03) :777-788

[6] CHROMOSOMAL MAPPING OF 2 GENETIC-LOCI ASSOCIATED WITH BLOOD-PRESSURE REGULATION IN HEREDITARY HYPERTENSIVE RATS [J].

HILBERT, P ;

LINDPAINTNER, K ;

BECKMANN, JS ;

SERIKAWA, T ;

SOUBRIER, F ;

DUBAY, C ;

CARTWRIGHT, P ;

DEGOUYON, B ;

JULIER, C ;

TAKAHASI, S ;

VINCENT, M ;

GANTEN, D ;

GEORGES, M ;

LATHROP, GM .

NATURE, 1991, 353 (6344) :521-529

[7] A GENETIC-LINKAGE MAP OF THE LABORATORY RAT, RATTUS-NORVEGICUS [J].

JACOB, HJ ;

BROWN, DM ;

BUNKER, RK ;

DALY, MJ ;

DZAU, VJ ;

GOODMAN, A ;

KOIKE, G ;

KREN, V ;

KURTZ, T ;

LERNMARK, A ;

LEVAN, G ;

MAO, YP ;

PETTERSSON, A ;

PRAVENEC, M ;

SIMON, JS ;

SZPIRER, C ;

SZPIRER, J ;

TROLLIET, MR ;

WINER, ES ;

LANDER, ES .

NATURE GENETICS, 1995, 9 (01) :63-69

[8] A RADIATION HYBRID MAP OF 506 STS MARKERS SPANNING HUMAN-CHROMOSOME-11 [J].

JAMES, MR ;

RICHARD, CW ;

SCHOTT, JJ ;

YOUSRY, C ;

CLARK, K ;

BELL, J ;

TERWILLIGER, JD ;

HAZAN, J ;

DUBAY, C ;

VIGNAL, A ;

AGRAPART, M ;

IMAI, T ;

NAKAMURA, Y ;

POLYMEROPOULOS, M ;

WEISSENBACH, J ;

COX, DR ;

LATHROP, GM .

NATURE GENETICS, 1994, 8 (01) :70-76

[9]

Kosambi D. D., 1944, ANN EUGENICS, V12, P172

[10] GENETIC DISSECTION OF COMPLEX TRAITS [J].

LANDER, ES ;

SCHORK, NJ .

SCIENCE, 1994, 265 (5181) :2037-2048

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