Store overload-induced Ca2+ release as a triggering mechanism for CPVT and MH episodes caused by mutations in RYR and CASQ genes

被引：74

作者：

MacLennan, David H. ^{[1
]}

Chen, S. R. Wayne ^{[2
,3
,4
]}

机构：

[1] Univ Toronto, Charles H Best Inst, Banting & Best Dept Med Res, Toronto, ON M5G 1L6, Canada

[2] Univ Calgary, Libin Cardiovasc Inst Alberta, Dept Physiol, Calgary, AB T2N 4N1, Canada

[3] Univ Calgary, Libin Cardiovasc Inst Alberta, Dept Biophys & Biochem, Calgary, AB T2N 4N1, Canada

[4] Univ Calgary, Libin Cardiovasc Inst Alberta, Dept Mol Biol, Calgary, AB T2N 4N1, Canada

来源：

JOURNAL OF PHYSIOLOGY-LONDON | 2009年 / 587卷 / 13期

基金：

加拿大健康研究院; 美国国家卫生研究院;

关键词：

POLYMORPHIC VENTRICULAR-TACHYCARDIA; CENTRAL CORE DISEASE; SARCOPLASMIC-RETICULUM; LUMINAL CA2+; MALIGNANT HYPERTHERMIA; CARDIAC CALSEQUESTRIN; RYANODINE-RECEPTORS; CALCIUM-RELEASE; SUDDEN-DEATH; INCREASE;

D O I：

10.1113/jphysiol.2009.172155

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

引用

页码：3113 / 3115

页数：3

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