The biosynthetic pathway of FK506 and its engineering: from past achievements to future prospects

被引：31
作者：
Ban, Yeon Hee [1 ]
Park, Sung Ryeol [2 ]
Yoon, Yeo Joon [1 ]
机构：
[1] Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South Korea
[2] Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA
来源：
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY | 2016年 / 43卷 / 2-3期
基金：
新加坡国家研究基金会;
关键词：
FK506; Biological activity; Biosynthetic pathway; Production improvement; analogs; Genetic engineering; STREPTOMYCES-TSUKUBAENSIS; CYCLOSPORINE-A; IMMUNOSUPPRESSANTS FK506; MUTATIONAL BIOSYNTHESIS; ANTIFUNGAL ACTIVITIES; TACROLIMUS PRODUCTION; GENE-CLUSTER; FK-506; FK520; CALCINEURIN;
D O I：
10.1007/s10295-015-1677-7
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
FK506, a 23-membered macrolide produced by several Streptomyces species, is an immunosuppressant widely used to prevent the rejection of transplanted organs. In addition, FK506 and its analogs possess numerous promising therapeutic potentials including antifungal, neuroprotective, and neuroregenerative activities. Herein, we introduce the biological activities and mechanisms of action of FK506 and discuss recent progress made in understanding its biosynthetic pathway, improving production, and in the mutasynthesis of diverse analogs. Perspectives highlighting further strain improvement and structural diversification aimed at generating more analogs with improved pharmaceutical properties will be emphasized.
引用
收藏
页码：389 / 400
页数：12
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