Dysprosium and Holmium Vanadate Nanoprobes as High- Performance Contrast Agents for High-Field Magnetic Resonance and Computed Tomography Imaging

被引：19

作者：

Gomez-Gonzalez, Elisabet ^{[1
]}

Nunez, Nuria O. ^{[1
]}

Caro, Carlos ^{[2
,3
]}

Garcia-Martin, Maria L. ^{[2
,3
]}

Fernandez-Afonso, Yilian ^{[4
]}

de la Fuente, Jesus M. ^{[3
,4
]}

Balcerzyk, Marcin ^{[5
,6
]}

Ocana, Manuel ^{[1
]}

机构：

[1] Inst Ciencia Mat Sevilla CSIC US, Seville 41092, Spain

[2] Junta Andalucia Univ Malaga, BIONAND, Andalusian Ctr Nanomed & Biotechnol, Malaga 29590, Spain

[3] CIBER BBN, Madrid 28029, Spain

[4] Univ Zaragoza, Inst Nanociencia & Mat Aragon INMA, CSIC, Zaragoza 50018, Spain

[5] Univ Seville, Ctr Nacl Aceleradores CNA, CSIC, Seville 41092, Spain

[6] Univ Seville, Fac Med, Dept Fisiol Med & Biofis, Seville 41009, Spain

来源：

INORGANIC CHEMISTRY | 2021年 / 60卷 / 01期

关键词：

NANOPARTICLES; MECHANISM; SIZE;

D O I：

10.1021/acs.inorgchem.0c02601

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

We describe a wet chemical method for the synthesis of uniform and well-dispersed dysprosium vanadate (DyVO4) and holmium vanadate (HoVO4) nanoparticles with an almost spherical shape and a mean size of similar to 60 nm and their functionalization with poly(acrylic acid). The transverse magnetic relaxivity of both systems at 9.4 T is analyzed on the basis of magnetic susceptibility and magnetization measurements in order to evaluate their potential for application as high-field MRI contrast agents. In addition, the X-ray attenuation properties of these systems are also studied to determine their capabilities as computed tomography contrast agent. Finally, the colloidal stability under physiological pH conditions and the cytotoxicity of the functionalized NPs are also addressed to assess their suitability for bioimaging applications.

引用

页码：152 / 160

页数：9

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