Androgen and prolactin (Prl) levels in systemic sclerosis (SSc) - Relationship to disease severity

被引：19
作者：
Mirone, Luisa
Barini, Angela
Barini, Antonella
机构：
[1] Univ Cattolica Sacro Cuore, Reumatol Cattedra Reumatol, UOC, Complesso Integrato Columbus, I-00168 Rome, Italy
[2] Univ Cattolica Sacro Cuore, Ist Biochim & Biochim Clin, I-00168 Rome, Italy
来源：
BASIC AND CLINICAL ASPECTS OF NEUROENDOCRINE IMMUNOLOGY IN RHEUMATIC DISEASES | 2006年 / 1069卷
关键词：
testosterone; dehydroepiandrosterone sulfate; prolactin; systemic sclerosis;
D O I：
10.1196/annals.1351.023
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Testosterone (T), sex hormone-binding globulin, (SHBG), dehydroepiandrosterone sulfate (DHEAS), and prolactin (Prl) serum levels were measured by electrochemiluminescense immunoassay (ECLIA) in 39 patients with systemic sclerosis (SSc) and compared with serum hormonal levels in control subjects matched for sex and reproductive status. A possible relationship with disease duration and disease severity was examined. Our data show an altered androgen and prolactin (Prl) status in SSc patients, in most cases related to disease duration and disease severity score. We can hypothesize that hormonal dysregulation is a consequence of the chronicity of the disease. The altered hormonal status could result in relative immunological hyperactivity contributing to enhance tissue damage and disease severity.
引用
收藏
页码：257 / 262
页数：6
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