Androgen and prolactin (Prl) levels in systemic sclerosis (SSc) - Relationship to disease severity

被引：19
作者：
Mirone, Luisa
Barini, Angela
Barini, Antonella
机构：
[1] Univ Cattolica Sacro Cuore, Reumatol Cattedra Reumatol, UOC, Complesso Integrato Columbus, I-00168 Rome, Italy
[2] Univ Cattolica Sacro Cuore, Ist Biochim & Biochim Clin, I-00168 Rome, Italy
来源：
BASIC AND CLINICAL ASPECTS OF NEUROENDOCRINE IMMUNOLOGY IN RHEUMATIC DISEASES | 2006年 / 1069卷
关键词：
testosterone; dehydroepiandrosterone sulfate; prolactin; systemic sclerosis;
D O I：
10.1196/annals.1351.023
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Testosterone (T), sex hormone-binding globulin, (SHBG), dehydroepiandrosterone sulfate (DHEAS), and prolactin (Prl) serum levels were measured by electrochemiluminescense immunoassay (ECLIA) in 39 patients with systemic sclerosis (SSc) and compared with serum hormonal levels in control subjects matched for sex and reproductive status. A possible relationship with disease duration and disease severity was examined. Our data show an altered androgen and prolactin (Prl) status in SSc patients, in most cases related to disease duration and disease severity score. We can hypothesize that hormonal dysregulation is a consequence of the chronicity of the disease. The altered hormonal status could result in relative immunological hyperactivity contributing to enhance tissue damage and disease severity.
引用
收藏
页码：257 / 262
页数：6
相关论文
共 50 条
  • [21] CXCL4 in undifferentiated connective tissue disease at risk for systemic sclerosis (SSc) (previously referred to as very early SSc)
    Gabriele Valentini
    Antonella Riccardi
    Serena Vettori
    Rosaria Irace
    Michele Iudici
    Salvatore Tolone
    Ludovico Docimo
    Marialuisa Bocchino
    Alessandro Sanduzzi
    Domenico Cozzolino
    Clinical and Experimental Medicine, 2017, 17 : 411 - 414
  • [22] Clinical significance of serum growth differentiation factor-15 levels in systemic sclerosis: association with disease severity
    Yanaba, Koichi
    Asano, Yoshihide
    Tada, Yayoi
    Sugaya, Makoto
    Kadono, Takafumi
    Sato, Shinichi
    MODERN RHEUMATOLOGY, 2012, 22 (05) : 668 - 675
  • [23] CXCL4 in undifferentiated connective tissue disease at risk for systemic sclerosis (SSc) (previously referred to as very early SSc)
    Valentini, Gabriele
    Riccardi, Antonella
    Vettori, Serena
    Irace, Rosaria
    Iudici, Michele
    Tolone, Salvatore
    Docimo, Ludovico
    Bocchino, Marialuisa
    Sanduzzi, Alessandro
    Cozzolino, Domenico
    CLINICAL AND EXPERIMENTAL MEDICINE, 2017, 17 (03) : 411 - 414
  • [24] Discordance between Patient and Physician Assessments of Disease Severity in Systemic Sclerosis
    Hudson, Marie
    Impens, Ann
    Baron, Murray
    Seibold, James R.
    Thombs, Brett D.
    Walker, Jennifer G.
    Steele, Russell
    JOURNAL OF RHEUMATOLOGY, 2010, 37 (11) : 2307 - 2312
  • [25] Does cigarette smoking mitigate the severity of skin disease in systemic sclerosis?
    Gyger, Genevieve
    Hudson, Marie
    Lo, Ernest
    Steele, Russell
    Baron, Murray
    RHEUMATOLOGY INTERNATIONAL, 2013, 33 (04) : 943 - 948
  • [26] Can microvascular damage predict disease severity in patients with systemic sclerosis?
    Martins, Ana
    Pimenta, Sofia
    Oliveira, Daniela
    Ferreira, Raquel Miriam
    Bernardes, Miguel
    Costa, Lucia
    Terroso, Georgina
    REUMATOLOGIA CLINICA, 2024, 20 (07): : 366 - 371
  • [27] Is Helicobacter pylori infection a risk factor for disease severity in systemic sclerosis?
    Radic, Mislav
    Kaliterna, Dusanka Martinovic
    Bonacin, Damir
    Vergles, Jadranka Morovic
    Radic, Josipa
    Fabijanic, Damir
    Kovacic, Vedran
    RHEUMATOLOGY INTERNATIONAL, 2013, 33 (11) : 2943 - 2948
  • [28] Prolactin in combination with interferon-β reduces disease severity in an animal model of multiple sclerosis
    Zhornitsky, Simon
    Johnson, Trina A.
    Metz, Luanne M.
    Weiss, Samuel
    Yong, V. Wee
    JOURNAL OF NEUROINFLAMMATION, 2015, 12
  • [29] Does cigarette smoking mitigate the severity of skin disease in systemic sclerosis?
    Geneviève Gyger
    Marie Hudson
    Ernest Lo
    Russell Steele
    Murray Baron
    Rheumatology International, 2013, 33 : 943 - 948
  • [30] DISEASE SEVERITY IS ASSOCIATED WITH OSTEOPOROSIS AND FRAGILITY FRACTURES IN PATIENTS WITH SYSTEMIC SCLEROSIS
    Midol, C.
    Wiebe, E.
    Siegert, E.
    Huscher, D.
    Behal, H.
    Launay, D.
    Hachulla, E.
    Sobanski, V.
    Buttgereit, F.
    ANNALS OF THE RHEUMATIC DISEASES, 2023, 82 : 162 - 163
12345