Androgen and prolactin (Prl) levels in systemic sclerosis (SSc) - Relationship to disease severity

被引：19

作者：

Mirone, Luisa

Barini, Angela

Barini, Antonella

机构：

[1] Univ Cattolica Sacro Cuore, Reumatol Cattedra Reumatol, UOC, Complesso Integrato Columbus, I-00168 Rome, Italy

[2] Univ Cattolica Sacro Cuore, Ist Biochim & Biochim Clin, I-00168 Rome, Italy

来源：

BASIC AND CLINICAL ASPECTS OF NEUROENDOCRINE IMMUNOLOGY IN RHEUMATIC DISEASES | 2006年 / 1069卷

关键词：

testosterone; dehydroepiandrosterone sulfate; prolactin; systemic sclerosis;

D O I：

10.1196/annals.1351.023

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Testosterone (T), sex hormone-binding globulin, (SHBG), dehydroepiandrosterone sulfate (DHEAS), and prolactin (Prl) serum levels were measured by electrochemiluminescense immunoassay (ECLIA) in 39 patients with systemic sclerosis (SSc) and compared with serum hormonal levels in control subjects matched for sex and reproductive status. A possible relationship with disease duration and disease severity was examined. Our data show an altered androgen and prolactin (Prl) status in SSc patients, in most cases related to disease duration and disease severity score. We can hypothesize that hormonal dysregulation is a consequence of the chronicity of the disease. The altered hormonal status could result in relative immunological hyperactivity contributing to enhance tissue damage and disease severity.

引用

页码：257 / 262

页数：6

共 50 条

[1] Enhanced serum prolactin (PRL) in patients with systemic lupus erythematosus: PRL levels are related to the disease activity
Jacobi, AM
Rohde, W
Ventz, M
Riemekasten, G
Burmester, GR
Hiepe, F
LUPUS, 2001, 10 (08) : 554 - 561
[2] RELATIONSHIP OF CARDIAC INVOLVEMENT WITH DISEASE SEVERITY IN PATIENTS OF SYSTEMIC SCLEROSIS
Dastgir, Noor
Qaisar, Wafa
Ilyas, Madiha
PAKISTAN HEART JOURNAL, 2022, 55 (01): : 33 - 36
[3] Clinical significance of serum hyaluronan levels in systemic sclerosis: Association with disease severity
Yoshizaki, Ayumi
Iwata, Yohei
Komura, Kazuhiro
Hara, Toshihide
Ogawa, Fumihide
Muroi, Eiji
Takenaka, Motoi
Shimizu, Kazuhiro
Hasegawa, Minoru
Fujimoto, Manabu
Sato, Shinichi
JOURNAL OF RHEUMATOLOGY, 2008, 35 (09) : 1825 - 1829
[4] Prevalence of Depression in Iraqi Patients with Systemic Sclerosis and Its Relationship with Disease Severity
Gorial, Faiq I.
Swady, Roaa Naji
INTERNATIONAL JOURNAL OF MEDICAL RESEARCH & HEALTH SCIENCES, 2018, 7 (04): : 69 - 74
[5] Evaluating sex hormone levels in reproductive age women with multiple sclerosis and their relationship with disease severity
Foroughipour, Azam
Norbakhsh, Vajihe
Najafabadi, Sara Hosseinpour
Meamar, Rokhsareh
JOURNAL OF RESEARCH IN MEDICAL SCIENCES, 2012, 17 (09): : 882 - 885
[6] Cartilage Oligomeric Matrix Protein (COMP) in systemic sclerosis (SSc): Role in disease severity and subclinical rheumatoid arthritis overlap
Gheita, Tamer A.
Hussein, Hani
JOINT BONE SPINE, 2012, 79 (01) : 51 - 56
[7] The relationship between peripheral T follicular helper cells and disease severity in systemic sclerosis
Sahinoglu, Melek
Sargin, Gokhan
Yavasoglu, Irfan
Senturk, Taskin
CLINICAL AND EXPERIMENTAL MEDICINE, 2024, 24 (01)
[8] High prolactin and low dehydroepiandrosterone sulphate serum levels in patients with severe systemic sclerosis
Straub, RH
Zeuner, M
Lock, G
Scholmerich, J
Lang, B
BRITISH JOURNAL OF RHEUMATOLOGY, 1997, 36 (04): : 426 - 432
[9] Prolactin and thyroid hormones in patients with systemic sclerosis: correlations with disease manifestations and activity
Shahin, AA
Abdoh, S
Abdelrazik, M
ZEITSCHRIFT FUR RHEUMATOLOGIE, 2002, 61 (06): : 703 - 709
[10] Serum levels of vascular dysfunction markers reflect disease severity and stage in systemic sclerosis patients
Cossu, Marta
Andracco, Romina
Santaniello, Alessandro
Marchini, Maurizio
Severino, Adriana
Caronni, Monica
Radstake, Timothy
Beretta, Lorenzo
RHEUMATOLOGY, 2016, 55 (06) : 1112 - 1116

← 1 2 3 4 5 →