Cross-complementation of Clostridium perfringens PLC and Clostridium septicum α-toxin mutants reveals PLC is sufficient to mediate gas gangrene

被引：21

作者：

Kennedy, Catherine L. ^{[1
]}

Lyras, Dena ^{[1
]}

Cheung, Jackie K. ^{[1
]}

Hiscox, Thomas J. ^{[1
]}

Emmins, John J. ^{[2
]}

Rood, Julian I. ^{[1
]}

机构：

[1] Monash Univ, Australian Bacterial Pathogenesis Res Program, Clayton, Vic 3800, Australia

[2] Monash Univ, Dept Immunol, Prahran, Vic 3004, Australia

来源：

MICROBES AND INFECTION | 2009年 / 11卷 / 03期

基金：

英国医学研究理事会;

关键词：

Perfringens; Septicum; alpha-Toxin; Pathogenesis; Myonecrosis; THETA-TOXIN; IDENTIFICATION; MYONECROSIS; ACTIVATION; VIRULENCE; MEMBRANES;

D O I：

10.1016/j.micinf.2009.01.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Clostridium perfringens and Clostridium septicum are the most common causes of clostridial myonecrosis or gas gangrene. Although they mediate a similar disease pathology, they elaborate functionally very different alpha-toxins. We used a reciprocal complementation approach to assess the contribution of the primary toxin of each species to disease and found that C. perfringens a-toxin (PLC) was able to mediate the gross pathology of myonecrosis even in a C. septicum background, although it could not induce vascular leukostasis. Conversely, while C. septicum alpha-toxin restored some virulence to a C. perfringens plc mutant, it was less active than in its native background. (C) 2009 Elsevier Masson SAS. All fights reserved.

引用

页码：413 / 418

页数：6

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