Enantioseparation on amylose tris(3,5-dimethoxyphenyl carbamate): Application to commercial pharmaceutical chiral drugs

被引：23
作者：
Cass, QB
Tiritan, ME
Calafatti, SA
Matlin, SA
机构：
[1] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP, Brazil
[2] Univ Sao Francisco, Unidade Farmacol, BR-12900000 Braganca Paulista, SP, Brazil
[3] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England
来源：
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES | 1999年 / 22卷 / 20期
基金：
巴西圣保罗研究基金会;
关键词：
D O I：
10.1081/JLC-100102077
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The enantioselectivity of the amylose tris(3,5-dimethoxyphenyl carbamate) phase towards some P-blockers was investigated. A sensitive HPLC method was developed for the enantiomers of metoprolol and betaxolol. The validated methods were suitable for the analysis of enantiomeric composition in a variety of pharmaceutical formulations of both drugs.
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收藏
页码：3091 / 3099
页数：9
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